Mouse Toll Like Receptor 6 (TLR6) CLIA Kit
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Description
Mouse Toll Like Receptor 6 (TLR6) Chemiluminescent Immunoassay (CLIA) Kit is a Sandwich Chemiluminescent Immunoassay (CLIA) Kit for use with Tissue homogenates, cell lysates, cell culture supernates and other biological fluids.
Documents del producto
Product specifications
| Category | CLIA Kits |
| Immunogen Target | Toll Like Receptor 6 (TLR6) |
| Reactivity | Mouse |
| Detection Method | Chemiluminescent |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 1.56 ng/ml - 100 ng/ml |
| Sensitivity | < 0.54 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | CLIA |
| Sample Type | Tissue homogenates, cell lysates, cell culture supernatants and other biological fluids. |
| Availability | Shipped within 5-20 working days. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| Alias | Toll-like receptor 6,CD286 |
| Background | CLIA Kits TLR6 |
| Status | RUO |
| Note | The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
Toll-like receptor 6 (TLR6) is a pattern-recognition receptor (PRR) in the toll-like receptor family that plays a critical role in the innate immune system. It is highly conserved across many species and primarily recognizes microbial components, particularly diacylated lipopeptides, which are lipid molecules derived from pathogens such as Gram-positive bacteria and certain fungi. TLR6 forms heterodimers with TLR2 to recognize these microbial products, allowing the immune system to detect the presence of pathogens and initiate a rapid immune response. TLR6 is expressed in various immune cells, including macrophages, dendritic cells, monocytes, neutrophils, and certain epithelial cells. Activation of TLR6 initiates downstream signaling cascades that promote the production of pro-inflammatory cytokines and chemokines, thereby coordinating immune responses and recruiting additional immune cells to the site of infection. This receptor also plays a role in tissue repair, and recent studies suggest its involvement in some chronic inflammatory and autoimmune diseases, as well as potential links to cancer. Understanding TLR6’s mechanisms and structure is essential for designing therapeutics that can modulate immune responses in a range of diseases.
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