Family main features
Natural Cytotoxicity Triggering Receptor 1 (NCR1), also known as NKp46 (Natural Killer Protein 46), is a type of activating receptor expressed predominantly on the surface of natural killer (NK) cells, a subset of lymphocytes that play an essential role in the immune system’s ability to recognize and eliminate infected or malignant cells. NCR1 is a critical component of the innate immune response, directly mediating NK cell cytotoxic activity. Unlike T and B cells that recognize specific antigens via receptors undergoing somatic recombination, NK cells use NCR1 and other natural cytotoxicity receptors to identify and kill target cells with stress-induced ligands or aberrant protein expression indicative of infection or transformation.
NCR1 interacts with a wide range of ligands, including viral proteins, bacterial components, and tumor-associated antigens, making it essential for defense against pathogens and cancer cells. This receptor operates independently of major histocompatibility complex (MHC) restriction, allowing it to respond quickly and efficiently to abnormal cells in the body. NCR1 is part of the natural cytotoxicity receptor (NCR) family, which also includes NCR2 (NKp44) and NCR3 (NKp30), and works in concert with other activating receptors like NKG2D to promote NK cell-mediated cytotoxicity.
NCR1 is a type I transmembrane protein that belongs to the immunoglobulin (Ig) superfamily, and its structure can be broken down into the following key domains:
Extracellular Domain:
Transmembrane Domain:
Intracellular Domain:
The unique structure of NCR1, including its Ig-like domains and interactions with signaling adaptors, enables it to respond to a wide variety of signals from abnormal cells, thereby triggering NK cell-mediated immune responses.
NCR1 is classified within the NCR family, a subset of activating receptors specifically expressed by NK cells. The NCR family comprises NCR1 (NKp46), NCR2 (NKp44), and NCR3 (NKp30). These receptors share structural homology due to their Ig-like domains but differ in their ligand specificities and roles in immune activation.
NCR1 is distinguished as the only NCR member expressed in both resting and activated NK cells across various tissues. Unlike other NCRs, NCR1 does not have known subtypes, although genetic polymorphisms in the NCR1 gene may influence its expression levels and functional activity, potentially impacting immune responses to infections and cancers.
Activation of NK Cells:
Recognition of Pathogen-Derived Ligands:
Tumor Surveillance:
Regulation of Immune Response in Autoimmunity:
Cancer Immunotherapy:
Infectious Diseases:
Autoimmune and Inflammatory Disorders:
Genetic Polymorphisms and Disease Susceptibility:
NCR1 (Natural Cytotoxicity Triggering Receptor 1) is an essential activating receptor expressed on NK cells, where it plays a central role in innate immune surveillance and defense against infections and malignancies. Structurally, NCR1 is a type I transmembrane protein of the Ig superfamily, consisting of an extracellular region with Ig-like domains, a transmembrane domain with a charged residue, and a short cytoplasmic tail. This structure enables NCR1 to bind various ligands associated with pathogenic or transformed cells and to recruit adaptor proteins (CD3ζ and FcεRIγ) for downstream signaling.
Functionally, NCR1 triggers NK cell cytotoxicity upon recognizing stress-induced ligands on infected, malignant, or transformed cells, leading to the release of cytotoxic granules and pro-inflammatory cytokines. NCR1 is involved in tumor surveillance and immune responses to pathogens, particularly viruses, and also plays a regulatory role in preventing autoimmunity by ensuring NK cells are appropriately activated.
In clinical settings, NCR1 is a target for immunotherapies against cancer, where enhancing its activity could improve NK cell-mediated tumor clearance. Additionally, NCR1's role in viral infections highlights its potential in antiviral therapies, while its dysregulation in autoimmune disorders underscores the need for balanced NCR1 activation. As research continues, NCR1 remains a critical focus for therapeutic development in cancer, infectious diseases, and autoimmunity.
natural cytotoxicity triggering receptor 1 (NCR1)
Lymphocyte antigen 94 homolog,LY94,CD335,NKP46,NK-p46,NK cell-activating receptor,Natural killer cell p46-related protein
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
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Abbexa | NCR1 | abx257675 | Human Natural Cytotoxicity Triggering Receptor 1 (NCR1) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | O76036 | RUO | ||
Abbexa | NCR1 | abx389990 | Mouse Natural Cytotoxicity Triggering Receptor 1 (NCR1) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 78 pg/ml - 5000 pg/ml | < 46.9 pg/ml | 687.5 | 96 tests | Q8C567 | RUO |
Abbexa | NCR1 | abx391668 | Rat Natural Cytotoxicity Triggering Receptor 1 (NCR1) ELISA Kit | Rat | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.094 ng/ml | 687.5 | 96 tests | Q9Z0H5 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | NCR1 | abx414080 | Natural Cytotoxicity Triggering Receptor 1 (NCR1) Antibody | Cow | Monoclonal | Mouse | Natural Cytotoxicity Triggering Receptor 1 (NCR1) | Unconjugated | WB, IF/ICC, FCM | 762.5 | 500 µg | Q863H2 | RUO | |
Abbexa | NCR1 | abx414081 | Natural Cytotoxicity Triggering Receptor 1 (NCR1) Antibody | Cow | Monoclonal | Mouse | Natural Cytotoxicity Triggering Receptor 1 (NCR1) | Unconjugated | WB, IF/ICC, FCM | 362.5 | 100 µg | Q863H2 | RUO | |
Abbexa | NCR1 | abx414082 | Natural Cytotoxicity Triggering Receptor 1 (NCR1) Antibody (PE) | Cow | Monoclonal | Mouse | Natural Cytotoxicity Triggering Receptor 1 (NCR1) | PE | FCM | 637.5 | 100 tests | Q863H2 | RUO | |
FineTest | NCR1 | FNab10472 | Anti-NCR1 antibody | human | polyclonal | Rabbit | Natural cytotoxicity triggering receptor 1 | IgG | Unconjugated | ELISA, WB, IHC, IF | 100µg | O76036 | RUO | |
Abbexa | NCR1 | abx336712 | Natural Cytotoxicity Triggering Receptor 1 (NCR1) Antibody (HRP) | Human | Polyclonal | Rabbit | Natural Cytotoxicity Triggering Receptor 1 (NCR1) | HRP | ELISA | 162.5 | 20 µg | O76036 | RUO | |
Abbexa | NCR1 | abx339912 | Natural Cytotoxicity Triggering Receptor 1 (NCR1) Antibody | Human | Polyclonal | Rabbit | Natural Cytotoxicity Triggering Receptor 1 (NCR1) | Unconjugated | ELISA, IHC | 250 | 50 µl | O76036 | RUO | |
Abbexa | NCR1 | abx336713 | Natural Cytotoxicity Triggering Receptor 1 (NCR1) Antibody (FITC) | Human | Polyclonal | Rabbit | Natural Cytotoxicity Triggering Receptor 1 (NCR1) | FITC | 162.5 | 20 µg | O76036 | RUO | ||
Abbexa | NCR1 | abx323433 | Natural Cytotoxicity Triggering Receptor 1 (NCR1) Antibody | Human | Polyclonal | Rabbit | Natural Cytotoxicity Triggering Receptor 1 (NCR1) | Unconjugated | ELISA, WB | 187.5 | 50 µg | O76036 | RUO | |
Abbexa | NCR1 | abx323434 | Natural Cytotoxicity Triggering Receptor 1 (NCR1) Antibody | Human | Polyclonal | Rabbit | Natural Cytotoxicity Triggering Receptor 1 (NCR1) | Unconjugated | ELISA, WB | 187.5 | 50 µg | O76036 | RUO | |
Abbexa | NCR1 | abx249454 | Natural Cytotoxicity Triggering Receptor 1 (NCR1) Antibody | Human | Polyclonal | Rabbit | Natural Cytotoxicity Triggering Receptor 1 (NCR1) | Unconjugated | ELISA, WB | 43.75 | 10 µg | O76036 | RUO | |
Abbexa | NCR1 | abx333883 | Natural Cytotoxicity Triggering Receptor 1 (NCR1) Antibody | Human | Polyclonal | Rabbit | Natural Cytotoxicity Triggering Receptor 1 (NCR1) | Unconjugated | ELISA, IHC, IF/ICC | 162.5 | 20 µg | O76036 | RUO | |
Abbexa | NCR1 | abx336714 | Natural Cytotoxicity Triggering Receptor 1 (NCR1) Antibody (Biotin) | Human | Polyclonal | Rabbit | Natural Cytotoxicity Triggering Receptor 1 (NCR1) | Biotin | ELISA | 162.5 | 20 µg | O76036 | RUO | |
Abbexa | NCR1 | abx004931 | Natural Cytotoxicity Triggering Receptor 1 (NCR1) Antibody | Human | Polyclonal | Rabbit | Natural Cytotoxicity Triggering Receptor 1 (NCR1) | Unconjugated | WB | 175 | 20 µl | O76036 | RUO | |
Abbexa | NCR1 | abx216441 | Natural Cytotoxicity Triggering Receptor 1 (NCR1) Antibody | Human | Polyclonal | Rabbit | Natural Cytotoxicity Triggering Receptor 1 (NCR1) | Unconjugated | ELISA, WB, IHC, IF/ICC | 350 | 100 µg | O76036 | RUO | |
Abbexa | NCR1 | abx211846 | Natural Cytotoxicity Triggering Receptor 1 (NCR1) Antibody | Human | Polyclonal | Rabbit | Natural Cytotoxicity Triggering Receptor 1 (NCR1) | Unconjugated | ELISA, WB, IHC | 250 | 50 µl | O76036 | RUO | |
Abbexa | NCR1 | abx130833 | Natural Cytotoxicity Triggering Receptor 1 (NCR1) Antibody | Mouse | Polyclonal | Rabbit | Natural Cytotoxicity Triggering Receptor 1 (NCR1) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | RUO | ||
Abbexa | NCR1 | abx274320 | Natural Cytotoxicity Triggering Receptor 1 (NCR1) Antibody (Biotin) | Mouse | Polyclonal | Rabbit | Natural Cytotoxicity Triggering Receptor 1 (NCR1) | Biotin | WB, IHC, IF/ICC | 362.5 | 200 µl | RUO | ||
Abbexa | NCR1 | abx229388 | CD335 Antibody (PE) | Mouse | Monoclonal | Rat | CD335 | IgG2a Kappa | PE | FCM | 200 | 50 tests | Q8C567 | RUO |
Abbexa | NCR1 | abx229389 | CD335 Antibody (APC) | Mouse | Monoclonal | Rat | CD335 | IgG2a Kappa | APC | FCM | 225 | 50 tests | Q8C567 | RUO |
Abbexa | NCR1 | abx229387 | CD335 Antibody (FITC) | Mouse | Monoclonal | Rat | CD335 | IgG2a Kappa | FITC | FCM | 200 | 50 tests | Q8C567 | RUO |
Abbexa | NCR1 | abx415295 | Natural Cytotoxicity Triggering Receptor 1 (NCR1) Antibody | Pig | Monoclonal | Mouse | Natural Cytotoxicity Triggering Receptor 1 (NCR1) | Unconjugated | IF/ICC, FCM | 362.5 | 100 µg | RUO | ||
Abbexa | NCR1 | abx415294 | Natural Cytotoxicity Triggering Receptor 1 (NCR1) Antibody (APC) | Pig | Monoclonal | Mouse | Natural Cytotoxicity Triggering Receptor 1 (NCR1) | APC | FCM | 637.5 | 100 tests | RUO | ||
Abbexa | NCR1 | abx130832 | Natural Cytotoxicity Triggering Receptor 1 (NCR1) Antibody | Rat | Polyclonal | Rabbit | Natural Cytotoxicity Triggering Receptor 1 (NCR1) | Unconjugated | WB, IHC, IF/ICC | 275 | 100 µl | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | NCR1 | abx168767 | Rat Natural Cytotoxicity Triggering Receptor 1 (NCR1) Protein | Rat | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 187.5 | 10 µg | Q9Z0H5 | RUO |
FineTest | NCR1 | P2279 | Recombinant Human CD335 | Human | Recombinant | E.Coli | Western Blot, ELISA | 50μg | O76036 | RUO | ||
Abbexa | NCR1 | abx168766 | Mouse Natural Cytotoxicity Triggering Receptor 1 (NCR1) Protein | Mouse | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 187.5 | 10 µg | Q8C567 | RUO |
Abbexa | NCR1 | abx680021 | Mouse Natural Cytotoxicity Triggering Receptor 1 (NCR1) Protein | Mouse | Recombinant | Insect | Unconjugated | SDS-PAGE | 225 | 1 µg | RUO |
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