Natural Cytotoxicity Triggering Receptor 1 (NCR1) Antibody
819€ (500 µg)
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935106861
info@markelab.com
name
Natural Cytotoxicity Triggering Receptor 1 (NCR1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx414080
tested applications
WB, IF/ICC, FCM
Description
Natural Cytotoxicity Triggering Receptor 1 (CD335) Antibody is a Mouse Monoclonal antibody against Natural Cytotoxicity Triggering Receptor 1 (CD335).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Natural Cytotoxicity Triggering Receptor 1 (NCR1) |
| Host | Mouse |
| Reactivity | Cow |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Purification | Purified |
| Size 1 | 500 µg |
| Form | Liquid |
| Tested Applications | WB, IF/ICC, FCM |
| Buffer | PBS. |
| Availability | Shipped within 3-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q863H2 |
| Alias | Lymphocyte antigen 94 homolog,LY94,CD335,NKP46,NK-p46,NK cell-activating receptor,Natural killer cell p46-related protein |
| Background | Antibody anti-NCR1 |
| Status | RUO |
| Note | Concentration: 1.0 mg/ml - |
Descripción
Natural Cytotoxicity Triggering Receptor 1 (NCR1), also known as NKp46 (Natural Killer Protein 46), is a type of activating receptor expressed predominantly on the surface of natural killer (NK) cells, a subset of lymphocytes that play an essential role in the immune system’s ability to recognize and eliminate infected or malignant cells. NCR1 is a critical component of the innate immune response, directly mediating NK cell cytotoxic activity. Unlike T and B cells that recognize specific antigens via receptors undergoing somatic recombination, NK cells use NCR1 and other natural cytotoxicity receptors to identify and kill target cells with stress-induced ligands or aberrant protein expression indicative of infection or transformation. NCR1 interacts with a wide range of ligands, including viral proteins, bacterial components, and tumor-associated antigens, making it essential for defense against pathogens and cancer cells. This receptor operates independently of major histocompatibility complex (MHC) restriction, allowing it to respond quickly and efficiently to abnormal cells in the body. NCR1 is part of the natural cytotoxicity receptor (NCR) family, which also includes NCR2 (NKp44) and NCR3 (NKp30), and works in concert with other activating receptors like NKG2D to promote NK cell-mediated cytotoxicity.
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