Anti-NCR1 antibody
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935106861
info@markelab.com
name
Anti-NCR1 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab10472
tested applications
ELISA, WB, IHC, IF
Description
The natural cytotoxicity receptors (NCRs) are a recently characterized family of Ig-like activation receptors that appear to be major triggering receptors in tumor cell recognition. NCR1 is a glycoprotein that has two extracellular Ig-like domains followed by a ~40 amino acid residue stalk region, a type I transmembrane domain, and a short cytoplasmic tail. NCR1 has been shown to represent a novel NK cell-specific molecule involved in human NK cell activation. NCR1 has been implicated in NK cell-mediated lysis of several autologous tumor cells and pathogen-infected cell lines.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Natural cytotoxicity triggering receptor 1 |
| Host | Rabbit |
| Reactivity | human,mouse |
| Recommended Dilution | WB: 1:500-1:2000; IHC: 1:50-1:200; IF: 1:50-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 46 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC, IF |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | O76036 |
| Gene ID | 9437 |
| Alias | Lymphocyte antigen 94 homolog,LY94,CD335,NKP46,NK-p46,NK cell-activating receptor,Natural killer cell p46-related protein |
| Background | Antibody anti-NCR1 |
| Status | RUO |
| Note | This product is for research use only. |
Descripción
Natural Cytotoxicity Triggering Receptor 1 (NCR1), also known as NKp46 (Natural Killer Protein 46), is a type of activating receptor expressed predominantly on the surface of natural killer (NK) cells, a subset of lymphocytes that play an essential role in the immune system’s ability to recognize and eliminate infected or malignant cells. NCR1 is a critical component of the innate immune response, directly mediating NK cell cytotoxic activity. Unlike T and B cells that recognize specific antigens via receptors undergoing somatic recombination, NK cells use NCR1 and other natural cytotoxicity receptors to identify and kill target cells with stress-induced ligands or aberrant protein expression indicative of infection or transformation. NCR1 interacts with a wide range of ligands, including viral proteins, bacterial components, and tumor-associated antigens, making it essential for defense against pathogens and cancer cells. This receptor operates independently of major histocompatibility complex (MHC) restriction, allowing it to respond quickly and efficiently to abnormal cells in the body. NCR1 is part of the natural cytotoxicity receptor (NCR) family, which also includes NCR2 (NKp44) and NCR3 (NKp30), and works in concert with other activating receptors like NKG2D to promote NK cell-mediated cytotoxicity.
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