Family main features
FLT3 (Fms-like tyrosine kinase 3), also known as CD135, is a cell-surface receptor primarily expressed on hematopoietic progenitor cells in the bone marrow and on certain immune cells, such as dendritic cells. Classified as a receptor tyrosine kinase (RTK), FLT3 belongs to the type III RTK family, which also includes the KIT, PDGFR, and CSF1R proteins. FLT3 plays a central role in the regulation of hematopoiesis by promoting the survival, proliferation, and differentiation of hematopoietic stem and progenitor cells (HSPCs).
The FLT3 ligand (FLT3L) is the primary growth factor that binds to and activates FLT3, resulting in downstream signaling essential for immune cell development. FLT3 has attracted significant scientific interest due to its implication in hematologic malignancies, especially acute myeloid leukemia (AML). Mutations in the FLT3 gene, particularly internal tandem duplications (ITDs) and point mutations in the tyrosine kinase domain (TKD), are common in AML and are associated with a poor prognosis. Consequently, FLT3 is a prominent target in therapeutic research, with several FLT3 inhibitors under development or in clinical use for the treatment of FLT3-mutated AML.
FLT3 is a type I transmembrane protein with a complex structure that is typical of receptor tyrosine kinases in the type III subclass. It has distinct extracellular, transmembrane, and intracellular regions, each critical for its function and ligand interaction:
Extracellular Domain:
Transmembrane Domain:
Intracellular (Cytoplasmic) Domain:
FLT3 is classified as part of the type III receptor tyrosine kinase (RTK) family, which is characterized by a ligand-binding extracellular region with five immunoglobulin-like domains, a single transmembrane domain, and a cytoplasmic split kinase domain. Type III RTKs are structurally distinct from other RTK classes due to this split kinase domain and their unique regulatory mechanisms.
FLT3 mutations are broadly divided into two types based on their location and mechanism of action:
FLT3 is integral to the development and function of hematopoietic cells. Its primary biological functions include:
Regulation of Hematopoiesis:
Immune System Modulation:
Downstream Signaling Pathways:
FLT3 activation triggers several downstream signaling pathways, including:
These signaling pathways collectively ensure the survival, proliferation, and differentiation of hematopoietic cells in response to FLT3 activation, particularly during immune responses or bone marrow stress.
Mutations and dysregulation of FLT3 signaling are strongly associated with hematologic malignancies, particularly AML. Major clinical issues related to FLT3 include:
Acute Myeloid Leukemia (AML):
Potential in Other Hematologic Disorders:
Drug Resistance:
FLT3 (CD135) is a receptor tyrosine kinase in the type III RTK family, essential for hematopoietic cell development and differentiation. Structurally, FLT3 consists of an extracellular ligand-binding domain with Ig-like domains, a transmembrane segment, and a split kinase domain crucial for signal transduction. Through its interaction with FLT3L, FLT3 supports the proliferation and survival of hematopoietic progenitor cells, especially those involved in immune responses.
FLT3 mutations, particularly ITDs and TKD mutations, are frequently observed in AML and confer poor prognoses due to their role in enhancing proliferation and reducing apoptosis. Consequently, FLT3 is a prominent therapeutic target, with several FLT3 inhibitors developed and used in clinical settings. Despite their efficacy, drug resistance remains a significant hurdle, necessitating combination strategies to improve long-term outcomes
fms related receptor tyrosine kinase 3 (FLT3)
Receptor-type tyrosine-protein kinase FLT3,FLK2,STK1,CD135,FLK-2,FL cytokine receptor,Fetal liver kinase-2,Fms-like tyrosine kinase 3,Stem cell tyrosine kinase 1
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, Primary Antibodies, ELISA Kits, CLIA Kits) relacionados con FLT3 - fms related receptor tyrosine kinase 3
Se muestran ordenados por categorías para poder comparar cómodamente sus características principales. Esta tabla, que contiene un enlace con la ficha de cada producto, es exportable a Excel.
Esta página contiene 49 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
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FineTest | FLT3 | EH0504 | Human FLT3(Receptor-type tyrosine-protein kinase FLT3) ELISA Kit | human | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich ELISA, Double Antibody | 62.5-4000pg/ml | 96T | P36888 | RUO | ||
Abbexa | FLT3 | abx151568 | Human Receptor-type tyrosine-protein kinase FLT3 (FLT3) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.312 ng/ml - 20 ng/ml | < 0.13 ng/ml | 618.75 | 96 tests | RUO | |
Abbexa | FLT3 | abx490804 | Human Receptor-type tyrosine-protein kinase FLT3 (FLT3) CLIA Kit | Human | Tissue homogenates, cell lysates and other biological fluids. | Sandwich | 0.312 ng/ml - 20 ng/ml | < 0.118 ng/ml | 812.5 | 96 tests | RUO | |
Abbexa | FLT3 | abx571974 | Human Receptor-type tyrosine-protein kinase FLT3 (FLT3) ELISA Kit | Human | Serum,Plasma,Other biological fluids | Sandwich | 78 pg/ml - 5000 pg/ml | 46.9 pg/ml | 525 | 96 tests | RUO | |
Abbexa | FLT3 | abx595232 | Receptor-type tyrosine-protein kinase FLT3 (FLT3) Cell ELISA Kit | Human | Cell ELISA | 493.75 | 96 tests | P36888 | RUO | |||
FineTest | FLT3 | EM1586 | Mouse FLT3(Receptor-type tyrosine-protein kinase FLT3) ELISA Kit | mouse | Busacar en las instrucciones | Sandwich ELISA, Double Antibody | 78.125-5000pg/ml | 96T | Q00342 | RUO | ||
Abbexa | FLT3 | abx254661 | Mouse Receptor-type tyrosine-protein kinase FLT3 (FLT3) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 31.2 pg/ml - 2000 pg/ml | < 15.63 pg/ml | 537.5 | 96 tests | Q00342 | RUO |
Abbexa | FLT3 | abx354543 | Mouse Receptor-type tyrosine-protein kinase FLT3 (FLT3) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.78 ng/ml - 50 ng/ml | 0.47 ng/ml | 562.5 | 96 tests | Q00342 | RUO |
FineTest | FLT3 | ERB0140 | Rabbit FLT3(Receptor-type tyrosine-protein kinase FLT3) ELISA Kit | rabbit | Busacar en las instrucciones | Sandwich ELISA, Double Antibody | 31.25-2000pg/ml | 96T | G1SMR5 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
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FineTest | FLT3 | FNab03164 | anti- FLT3 antibody | human | polyclonal | Rabbit | fms-related tyrosine kinase 3 | IgG | Unconjugated | ELISA, WB, IP | 100µg | P36888 | RUO | |
Abbexa | FLT3 | abx324723 | Receptor-type tyrosine-protein kinase FLT3 Phospho-Tyr969 (FLT3 pY969) Antibody | Human | Polyclonal | Rabbit | Receptor-type tyrosine-protein kinase FLT3 Phospho-Tyr969 (FLT3 pY969) | Unconjugated | ELISA, WB, IHC | 187.5 | 50 µg | P36888 | RUO | |
Abbexa | FLT3 | abx341881 | Receptor-type tyrosine-protein kinase FLT3 (FLT3) Antibody (Biotin) | Human | Polyclonal | Rabbit | Receptor-type tyrosine-protein kinase FLT3 (FLT3) | Biotin | ELISA | 250 | 50 µl | P36888 | RUO | |
Abbexa | FLT3 | abx172451 | Receptor-type tyrosine-protein kinase FLT3 (FLT3) Antibody | Human | Monoclonal | Mouse | Receptor-type tyrosine-protein kinase FLT3 (FLT3) | Unconjugated | WB, IHC, IF/ICC | 712.5 | 1 ml | RUO | ||
Abbexa | FLT3 | abx341880 | Receptor-type tyrosine-protein kinase FLT3 (FLT3) Antibody (FITC) | Human | Polyclonal | Rabbit | Receptor-type tyrosine-protein kinase FLT3 (FLT3) | FITC | 250 | 50 µl | P36888 | RUO | ||
Abbexa | FLT3 | abx123302 | FLT3 (pY589 / 591) Antibody | Human | Polyclonal | Rabbit | FLT3 (pY589/591) | Unconjugated | WB | 200 | 20 µl | P36888 | RUO | |
Abbexa | FLT3 | abx119539 | FLT3 (pY969) Antibody | Human | Polyclonal | Rabbit | FLT3 (pY969) | Unconjugated | WB, IHC | 43.75 | 10 µg | P36888 | RUO | |
Abbexa | FLT3 | abx013506 | Flt3 ligand Antibody | Human | Polyclonal | Rabbit | Flt3 ligand | Unconjugated | ELISA, WB | 43.75 | 10 µg | P49771 | RUO | |
Abbexa | FLT3 | abx139447 | Receptor-Type Tyrosine-Protein Kinase FLT3 (FLT3) Antibody | Human | Monoclonal | Mouse | Receptor-Type Tyrosine-Protein Kinase FLT3 (FLT3) | Unconjugated | FCM, IP | 275 | 0.1 mg | P36888 | RUO | |
Abbexa | FLT3 | abx341878 | Receptor-type tyrosine-protein kinase FLT3 (FLT3) Antibody | Human | Polyclonal | Rabbit | Receptor-type tyrosine-protein kinase FLT3 (FLT3) | Unconjugated | ELISA, WB | 250 | 50 µl | P36888 | RUO | |
Abbexa | FLT3 | abx139449 | Receptor-type tyrosine-protein kinase FLT3 (FLT3) Antibody (PE) | Human | Monoclonal | Mouse | Receptor-type tyrosine-protein kinase FLT3 (FLT3) | PE | FCM | 400 | 100 tests | P36888 | RUO | |
Abbexa | FLT3 | abx341879 | Receptor-type tyrosine-protein kinase FLT3 (FLT3) Antibody (HRP) | Human | Polyclonal | Rabbit | Receptor-type tyrosine-protein kinase FLT3 (FLT3) | HRP | ELISA | 250 | 50 µl | P36888 | RUO | |
Abbexa | FLT3 | abx139448 | CD135 Antibody (FITC) | Human | Monoclonal | Mouse | CD135 | FITC | FCM | 350 | 100 tests | P36888 | RUO | |
Abbexa | FLT3 | abx015860 | Receptor-Type Tyrosine-Protein Kinase FLT3 (FLT3) Antibody | Human | Monoclonal | Mouse | Receptor-Type Tyrosine-Protein Kinase FLT3 (FLT3) | Unconjugated | ELISA, IHC | 362.5 | 100 µl | P36888 | RUO | |
Abbexa | FLT3 | abx128669 | Receptor-type tyrosine-protein kinase FLT3 (FLT3) Antibody | Human | Polyclonal | Rabbit | Receptor-type tyrosine-protein kinase FLT3 (FLT3) | Unconjugated | WB, IHC, IF/ICC | 250 | 100 µl | P36888 | RUO | |
Abbexa | FLT3 | abx033568 | Receptor-type tyrosine-protein kinase FLT3 (FLT3) Antibody | Human | Polyclonal | Rabbit | Receptor-type tyrosine-protein kinase FLT3 (FLT3) | Unconjugated | ELISA, WB, IHC, FCM | 250 | 80 µl | P36888 | RUO | |
Abbexa | FLT3 | abx325459 | Receptor-type tyrosine-protein kinase FLT3 (FLT3) Antibody | Human | Polyclonal | Rabbit | Receptor-type tyrosine-protein kinase FLT3 (FLT3) | Unconjugated | ELISA, WB | 187.5 | 50 µg | P36888 | RUO | |
Abbexa | FLT3 | abx012600 | Receptor-type tyrosine-protein kinase FLT3 Phospho-Tyr842 (FLT3 pY842) Antibody | Human | Polyclonal | Rabbit | Receptor-type tyrosine-protein kinase FLT3 Phospho-Tyr842 (FLT3 pY842) | Unconjugated | ELISA, WB | 43.75 | 10 µg | P36888 | RUO | |
Abbexa | FLT3 | abx037735 | Receptor-type tyrosine-protein kinase FLT3 (FLT3) Antibody | Human | Polyclonal | Rabbit | Receptor-type tyrosine-protein kinase FLT3 (FLT3) | Unconjugated | ELISA, WB, IHC | 337.5 | 100 µg | RUO | ||
Abbexa | FLT3 | abx333060 | FLT3 (pY842) Antibody | Human | Polyclonal | Rabbit | FLT3 (pY842) | Unconjugated | ELISA, WB | 412.5 | 100 µl | P36888 | RUO | |
Abbexa | FLT3 | abx212890 | Receptor-type tyrosine-protein kinase FLT3 (FLT3) Antibody | Human | Polyclonal | Rabbit | Receptor-type tyrosine-protein kinase FLT3 (FLT3) | Unconjugated | ELISA, IHC | 250 | 50 µl | P36888 | RUO | |
Abbexa | FLT3 | abx325381 | Receptor-type tyrosine-protein kinase FLT3 Phospho-Tyr842 (FLT3 pY842) Antibody | Human | Polyclonal | Rabbit | Receptor-type tyrosine-protein kinase FLT3 Phospho-Tyr842 (FLT3 pY842) | Unconjugated | ELISA, WB | 187.5 | 50 µg | P36888 | RUO | |
Abbexa | FLT3 | abx326281 | Receptor-type tyrosine-protein kinase FLT3 Phospho-Tyr599 (FLT3 pY599) Antibody | Human | Polyclonal | Rabbit | Receptor-type tyrosine-protein kinase FLT3 Phospho-Tyr599 (FLT3 pY599) | Unconjugated | ELISA, WB | 187.5 | 50 µg | P36888 | RUO | |
Abbexa | FLT3 | abx214028 | Receptor-type tyrosine-protein kinase FLT3 (FLT3) Antibody | Human | Polyclonal | Rabbit | Receptor-type tyrosine-protein kinase FLT3 (FLT3) | Unconjugated | ELISA, WB, IHC | 250 | 50 µl | P36888 | RUO | |
Abbexa | FLT3 | abx327231 | Receptor-type tyrosine-protein kinase FLT3 (FLT3) Antibody | Human | Polyclonal | Rabbit | Receptor-type tyrosine-protein kinase FLT3 (FLT3) | Unconjugated | ELISA, WB | 187.5 | 50 µg | P36888 | RUO | |
Abbexa | FLT3 | abx233164 | Receptor-type tyrosine-protein kinase FLT3 (FLT3) Antibody | Human | Polyclonal | Rabbit | Receptor-type tyrosine-protein kinase FLT3 (FLT3) | Unconjugated | ELISA, WB, IP | 350 | 100 µg | P36888 | RUO | |
Abbexa | FLT3 | abx112563 | Receptor-type tyrosine-protein kinase FLT3 (FLT3) Antibody | Human | Polyclonal | Rabbit | Receptor-type tyrosine-protein kinase FLT3 (FLT3) | Unconjugated | ELISA, WB | 612.5 | 100 µl | P36888 | RUO | |
Abbexa | FLT3 | abx129609 | Receptor-type tyrosine-protein kinase FLT3 (FLT3) Antibody | Mouse | Polyclonal | Rabbit | Receptor-type tyrosine-protein kinase FLT3 (FLT3) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | RUO | ||
Abbexa | FLT3 | abx028182 | Receptor-type tyrosine-protein kinase FLT3 (FLT3) Antibody | Mouse | Polyclonal | Rabbit | Receptor-type tyrosine-protein kinase FLT3 (FLT3) | Unconjugated | ELISA, WB | 250 | 80 µl | Q00342 | RUO | |
Abbexa | FLT3 | abx274553 | Receptor-type tyrosine-protein kinase FLT3 (FLT3) Antibody (Biotin) | Mouse | Polyclonal | Rabbit | Receptor-type tyrosine-protein kinase FLT3 (FLT3) | Biotin | WB, IHC, IF/ICC | 337.5 | 200 µl | RUO | ||
Abbexa | FLT3 | abx007087 | Receptor-type tyrosine-protein kinase FLT3 (FLT3) Antibody | Mouse | Polyclonal | Rabbit | Receptor-type tyrosine-protein kinase FLT3 (FLT3) | Unconjugated | WB | 175 | 20 µl | P36888 | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | FLT3 | abx263193 | Flt3-Ligand, HEK Protein | Human | Recombinant | Unconjugated | SDS-PAGE | 225 | 2 µg | P49771 | RUO | |
Abbexa | FLT3 | abx263192 | Flt3-Ligand, Sf9 Protein | Human | Recombinant | Unconjugated | SDS-PAGE | 225 | 2 µg | P49771 | RUO | |
Abbexa | FLT3 | abx167058 | Human Receptor-type tyrosine-protein kinase FLT3 (FLT3) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 225 | 10 µg | P36888 | RUO |
Abbexa | FLT3 | abx167437 | Mouse Receptor-type tyrosine-protein kinase FLT3 (FLT3) Protein | Mouse | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 225 | 10 µg | Q00342 | RUO |
FineTest | FLT3 | P5279 | Recombinant Mouse Flt3 ligand | Mouse | Recombinant | E.Coli | Western Blot,ELISA | 50μg | P49772 | RUO | ||
Abbexa | FLT3 | abx261850 | Flt3-Ligand Protein | Human | Recombinant | Unconjugated | SDS-PAGE | 225 | 2 µg | P49771 | RUO | |
FineTest | FLT3 | P5278 | Recombinant Human Flt3 ligand | Human | Recombinant | E.Coli | Western Blot,ELISA | 50μg | P49771 | RUO | ||
Abbexa | FLT3 | abx261849 | Flt3-Ligand Protein | Monkey | Recombinant | Unconjugated | SDS-PAGE | 225 | 2 µg | RUO | ||
Abbexa | FLT3 | abx261757 | Flt3-Ligand Protein | Human | Recombinant | Unconjugated | SDS-PAGE | 225 | 5 µg | P49771 | RUO |
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