Receptor-type tyrosine-protein kinase FLT3 Phospho-Tyr599 (FLT3 pY599) Antibody
Pida mas información
935106861
info@markelab.com
Precio
187.5€ (50 µg)
Antibody anti-FLT3
proveedor
Abbexareference
abx326281Tested Applications
ELISA, WBreactivity
Human, Mouse, Monkeystatus
RUOclonality
PolyclonalDescripción
FLT3 (pY599) Antibody is a Rabbit Polyclonal against FLT3 (pY599).
Background
FLT3 (Fms-like tyrosine kinase 3), also known as CD135, is a cell-surface receptor primarily expressed on hematopoietic progenitor cells in the bone marrow and on certain immune cells, such as dendritic cells. Classified as a receptor tyrosine kinase (RTK), FLT3 belongs to the type III RTK family, which also includes the KIT, PDGFR, and CSF1R proteins. FLT3 plays a central role in the regulation of hematopoiesis by promoting the survival, proliferation, and differentiation of hematopoietic stem and progenitor cells (HSPCs). The FLT3 ligand (FLT3L) is the primary growth factor that binds to and activates FLT3, resulting in downstream signaling essential for immune cell development. FLT3 has attracted significant scientific interest due to its implication in hematologic malignancies, especially acute myeloid leukemia (AML). Mutations in the FLT3 gene, particularly internal tandem duplications (ITDs) and point mutations in the tyrosine kinase domain (TKD), are common in AML and are associated with a poor prognosis. Consequently, FLT3 is a prominent target in therapeutic research, with several FLT3 inhibitors under development or in clinical use for the treatment of FLT3-mutated AML.
Características del producto
category
Primary Antibodies
clonality
Polyclonal
reactivity
Human, Mouse, Monkey
immunogen target
Receptor-type tyrosine-protein kinase FLT3 Phospho-Tyr599 (FLT3 pY599)
host
Rabbit
conjugation
Unconjugated
form
Liquid
tested applications
ELISA, WB
purification
Purified by affinity chromatography.
buffer
PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
size 1
50 µg
size 2
100 µg
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
FLT3
dry ice
No
availability
Shipped within 5-10 working days.
alias
Receptor-type tyrosine-protein kinase FLT3,FLK2,STK1,CD135,FLK-2,FL cytokine receptor,Fetal liver kinase-2,Fms-like tyrosine kinase 3,Stem cell tyrosine kinase 1
uniprot id
note
This product is for research use only.
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