Receptor-type tyrosine-protein kinase FLT3 Phospho-Tyr599 (FLT3 pY599) Antibody

Este producto es parte de FLT3 - fms related receptor tyrosine kinase 3
Receptor-type tyrosine-protein kinase FLT3 Phospho-Tyr599 (FLT3 pY599) Antibody

Pida mas información

935106861

info@markelab.com

Precio

187.5€ (50 µg)

Antibody anti-FLT3

proveedor

Abbexa

reference

abx326281

Tested Applications

ELISA, WB

reactivity

Human, Mouse, Monkey

status

RUO

clonality

Polyclonal

Descripción

FLT3 (pY599) Antibody is a Rabbit Polyclonal against FLT3 (pY599).


Background

FLT3 (Fms-like tyrosine kinase 3), also known as CD135, is a cell-surface receptor primarily expressed on hematopoietic progenitor cells in the bone marrow and on certain immune cells, such as dendritic cells. Classified as a receptor tyrosine kinase (RTK), FLT3 belongs to the type III RTK family, which also includes the KIT, PDGFR, and CSF1R proteins. FLT3 plays a central role in the regulation of hematopoiesis by promoting the survival, proliferation, and differentiation of hematopoietic stem and progenitor cells (HSPCs). The FLT3 ligand (FLT3L) is the primary growth factor that binds to and activates FLT3, resulting in downstream signaling essential for immune cell development. FLT3 has attracted significant scientific interest due to its implication in hematologic malignancies, especially acute myeloid leukemia (AML). Mutations in the FLT3 gene, particularly internal tandem duplications (ITDs) and point mutations in the tyrosine kinase domain (TKD), are common in AML and are associated with a poor prognosis. Consequently, FLT3 is a prominent target in therapeutic research, with several FLT3 inhibitors under development or in clinical use for the treatment of FLT3-mutated AML.

Características del producto

category

Primary Antibodies


clonality

Polyclonal


reactivity

Human, Mouse, Monkey


immunogen target

Receptor-type tyrosine-protein kinase FLT3 Phospho-Tyr599 (FLT3 pY599)


host

Rabbit


conjugation

Unconjugated


form

Liquid


tested applications

ELISA, WB


purification

Purified by affinity chromatography.


buffer

PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.


size 1

50 µg


size 2

100 µg


storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.


or code

FLT3


dry ice

No


availability

Shipped within 5-10 working days.


alias

Receptor-type tyrosine-protein kinase FLT3,FLK2,STK1,CD135,FLK-2,FL cytokine receptor,Fetal liver kinase-2,Fms-like tyrosine kinase 3,Stem cell tyrosine kinase 1


note

This product is for research use only.


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