Receptor-Type Tyrosine-Protein Kinase FLT3 (FLT3) Antibody

Este producto es parte de FLT3 - fms related receptor tyrosine kinase 3
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299€ (0.1 mg)

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935106861
info@markelab.com
name
Receptor-Type Tyrosine-Protein Kinase FLT3 (FLT3) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx139447
tested applications
FCM, IP

Description

FLT3/CD135 Antibody is a Mouse Monoclonal against FLT3/CD135.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Receptor-Type Tyrosine-Protein Kinase FLT3 (FLT3)
Host
Mouse
Reactivity
Human
Recommended Dilution
FCM: 1-4 µg/ml. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Monoclonal
Conjugation
Unconjugated
Isotype
IgG1
Clone ID
M931
Purity
> 95% (SDS-PAGE)
Purification
Purified by Protein A affinity chromatography.
Size 1
0.1 mg
Tested Applications
FCM, IP
Buffer
PBS, pH 7.4, containing 15 mM sodium azide.
Availability
Shipped within 5-12 working days.
Storage
Store at 2-8°C. Do not freeze.
Dry Ice
No
UniProt ID
P36888
Gene ID
2322
Alias
Receptor-type tyrosine-protein kinase FLT3,FLK2,STK1,CD135,FLK-2,FL cytokine receptor,Fetal liver kinase-2,Fms-like tyrosine kinase 3,Stem cell tyrosine kinase 1
Background
Antibody anti-FLT3
Status
RUO
Note
Concentration: 1 mg/ml - 

Descripción

FLT3 (Fms-like tyrosine kinase 3), also known as CD135, is a cell-surface receptor primarily expressed on hematopoietic progenitor cells in the bone marrow and on certain immune cells, such as dendritic cells. Classified as a receptor tyrosine kinase (RTK), FLT3 belongs to the type III RTK family, which also includes the KIT, PDGFR, and CSF1R proteins. FLT3 plays a central role in the regulation of hematopoiesis by promoting the survival, proliferation, and differentiation of hematopoietic stem and progenitor cells (HSPCs). The FLT3 ligand (FLT3L) is the primary growth factor that binds to and activates FLT3, resulting in downstream signaling essential for immune cell development. FLT3 has attracted significant scientific interest due to its implication in hematologic malignancies, especially acute myeloid leukemia (AML). Mutations in the FLT3 gene, particularly internal tandem duplications (ITDs) and point mutations in the tyrosine kinase domain (TKD), are common in AML and are associated with a poor prognosis. Consequently, FLT3 is a prominent target in therapeutic research, with several FLT3 inhibitors under development or in clinical use for the treatment of FLT3-mutated AML.

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