Receptor-Type Tyrosine-Protein Kinase FLT3 (FLT3) Antibody
383.5€ (100 µl)
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935106861
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name
Receptor-Type Tyrosine-Protein Kinase FLT3 (FLT3) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx015860
tested applications
ELISA, IHC
Description
This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Receptor-Type Tyrosine-Protein Kinase FLT3 (FLT3) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/10000, IHC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Clone ID | M049 |
| Purification | Purified from ascites by Protein G chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS, containing 0.05% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P36888 |
| Gene ID | 2322 |
| OMIM | 136351 |
| Alias | Receptor-type tyrosine-protein kinase FLT3,FLK2,STK1,CD135,FLK-2,FL cytokine receptor,Fetal liver kinase-2,Fms-like tyrosine kinase 3,Stem cell tyrosine kinase 1 |
| Background | Antibody anti-FLT3 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
FLT3 (Fms-like tyrosine kinase 3), also known as CD135, is a cell-surface receptor primarily expressed on hematopoietic progenitor cells in the bone marrow and on certain immune cells, such as dendritic cells. Classified as a receptor tyrosine kinase (RTK), FLT3 belongs to the type III RTK family, which also includes the KIT, PDGFR, and CSF1R proteins. FLT3 plays a central role in the regulation of hematopoiesis by promoting the survival, proliferation, and differentiation of hematopoietic stem and progenitor cells (HSPCs). The FLT3 ligand (FLT3L) is the primary growth factor that binds to and activates FLT3, resulting in downstream signaling essential for immune cell development. FLT3 has attracted significant scientific interest due to its implication in hematologic malignancies, especially acute myeloid leukemia (AML). Mutations in the FLT3 gene, particularly internal tandem duplications (ITDs) and point mutations in the tyrosine kinase domain (TKD), are common in AML and are associated with a poor prognosis. Consequently, FLT3 is a prominent target in therapeutic research, with several FLT3 inhibitors under development or in clinical use for the treatment of FLT3-mutated AML.
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