Family main features
CLEC10A (C-type lectin domain containing 10A), also known as CD301 or MGL (Macrophage Galactose-Type Lectin), is a transmembrane protein in the C-type lectin receptor (CLR) family primarily expressed on antigen-presenting cells such as dendritic cells, macrophages, and certain monocytes. CLEC10A is part of the innate immune system, specializing in recognizing carbohydrate structures on the surfaces of cells and pathogens. Specifically, it binds to terminal galactose and N-acetylgalactosamine (GalNAc) residues, making it essential for identifying certain pathogens and interacting with glycoproteins on cellular surfaces.
CLEC10A’s specificity for galactose-containing glycans allows it to function in immune surveillance, pathogen clearance, and immunomodulation, making it a focal point in immune-related research. Its expression on dendritic cells and macrophages positions it to play a key role in the innate immune system's interactions with the adaptive immune response, particularly in tissue immune environments. CLEC10A’s involvement in recognizing glycosylated antigens has implications for disease processes, including infections, cancer, and autoimmune conditions.
CLEC10A’s structure is optimized for its role in glycan recognition and immune cell signaling:
C-type Lectin Domain (CTLD):
Extracellular Stalk Region:
Transmembrane Domain:
Cytoplasmic Tail:
CLEC10A is a member of the C-type lectin receptor family and is classified within group II of the C-type lectins, which are typically transmembrane proteins involved in immune functions. It shares structural similarity with other C-type lectins but is unique in its specificity for GalNAc and terminal galactose residues. This specificity distinguishes it from other lectins, such as DC-SIGN and CLEC4M (L-SIGN), which bind different carbohydrate structures. CLEC10A does not have defined subtypes; however, its functions may be modulated through interactions with various co-receptors or other cell-surface proteins in tissue-specific immune environments.
CLEC10A has a distinct role in immune recognition and modulation due to its unique glycan specificity:
Glycan Recognition and Pathogen Binding:
Endocytosis and Antigen Processing:
Immune Regulation and Tolerance:
Role in Cancer:
CLEC10A has been linked to several clinical conditions, given its role in immune surveillance and glycan recognition:
Infectious Diseases:
Autoimmune Disorders:
Cancer:
Allergic Inflammation:
CLEC10A (CD301/MGL) is a C-type lectin receptor primarily expressed on macrophages and dendritic cells, where it recognizes terminal galactose and GalNAc residues on glycosylated antigens. Its structure, with a well-defined C-type lectin domain, transmembrane domain, and cytoplasmic tail, supports its function in pathogen recognition, immune regulation, and potentially in immune tolerance. CLEC10A’s unique carbohydrate specificity situates it as a crucial receptor in pathogen capture, immune modulation, and even immune surveillance in cancer, given its capacity to bind to tumor-associated glycan structures.
Clinically, CLEC10A is implicated in various conditions, including infectious diseases, autoimmune disorders, and cancer, largely due to its ability to recognize both self and foreign glycosylated antigens. By participating in immune surveillance, CLEC10A modulates innate immune responses and serves as a bridge to adaptive immunity, particularly through endocytosis and antigen processing. Its role in recognizing abnormal glycosylation patterns makes it a potential target for therapeutic approaches in infectious disease, cancer, and autoimmune conditions. As research advances, CLEC10A remains a key focus in understanding glycan-dependent immune processes and their applications in immunology and therapeutic development.
C-type lectin domain containing 10A (CLEC10A)
C-type lectin domain family 10 member A,HML,MGL,HML2,CD301,CLECSF13,CLECSF14,C-type lectin superfamily member 14,Macrophage lectin 2
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Esta página contiene 30 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | CLEC10A | abx259489 | Human C-Type Lectin Domain Family 10 Member A / CD301 (CLEC10A) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.313 ng/ml - 20 ng/ml | < 0.188 ng/ml | 687.5 | 96 tests | Q8IUN9 | RUO |
Abbexa | CLEC10A | abx258830 | Mouse C-Type Lectin Domain Family 10 Member A / CD301 (CLEC10A) ELISA Kit | Mouse | Serum,Plasma,Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.07 ng/ml | 687.5 | 96 tests | P49300 | RUO |
Abbexa | CLEC10A | abx496434 | Mouse C-Type Lectin Domain Family 10 Member A / CD301 (CLEC10A) CLIA Kit | Mouse | Serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids. | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.063 ng/ml | 812.5 | 96 tests | P49300 | RUO |
Abbexa | CLEC10A | abx507099 | Rat C-Type Lectin Domain Family 10 Member A (CLEC10A) ELISA Kit | Rat | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | P49301 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
FineTest | CLEC10A | FNab01745 | anti- CLEC10A/CD301 antibody | human | polyclonal | Rabbit | C-type lectin domain family 10, member A | IgG | Unconjugated | ELISA, WB | 100µg | Q8IUN9 | RUO | |
Abbexa | CLEC10A | abx340747 | C-type lectin domain family 10 member A (CLEC10A) Antibody | Human | Polyclonal | Rabbit | C-type lectin domain family 10 member A (CLEC10A) | Unconjugated | ELISA, IHC, IF/ICC | 250 | 50 µl | Q8IUN9 | RUO | |
Abbexa | CLEC10A | abx340750 | C-type lectin domain family 10 member A (CLEC10A) Antibody (Biotin) | Human | Polyclonal | Rabbit | C-type lectin domain family 10 member A (CLEC10A) | Biotin | ELISA | 250 | 50 µl | Q8IUN9 | RUO | |
Abbexa | CLEC10A | abx104270 | C-Type Lectin Domain Family 10 Member A / CD301 (CLEC10A) Antibody | Human | Polyclonal | Rabbit | C-Type Lectin Domain Family 10 Member A / CD301 (CLEC10A) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | RUO | ||
Abbexa | CLEC10A | abx231745 | C-Type Lectin Domain Family 10 Member A / CD301 (CLEC10A) Antibody | Human | Polyclonal | Rabbit | C-Type Lectin Domain Family 10 Member A / CD301 (CLEC10A) | Unconjugated | ELISA, WB | 350 | 100 µg | Q8IUN9 | RUO | |
Abbexa | CLEC10A | abx339732 | C-Type Lectin Domain Family 10 Member A / CD301 (CLEC10A) Antibody | Human | Polyclonal | Rabbit | C-Type Lectin Domain Family 10 Member A / CD301 (CLEC10A) | Unconjugated | ELISA, IHC | 250 | 50 µl | Q8IUN9 | RUO | |
Abbexa | CLEC10A | abx025781 | C-Type Lectin Domain Family 10 Member A / CD301 (CLEC10A) Antibody | Human | Polyclonal | Rabbit | C-Type Lectin Domain Family 10 Member A / CD301 (CLEC10A) | Unconjugated | ELISA, WB, FCM | 250 | 80 µl | Q8IUN9 | RUO | |
Abbexa | CLEC10A | abx111839 | C-Type Lectin Domain Family 10 Member A / CD301 (CLEC10A) Antibody | Human | Polyclonal | Rabbit | C-Type Lectin Domain Family 10 Member A / CD301 (CLEC10A) | Unconjugated | ELISA, WB | 612.5 | 100 µl | Q8IUN9 | RUO | |
Abbexa | CLEC10A | abx145766 | C-Type Lectin Domain Family 10 Member A / CD301 (CLEC10A) Antibody | Human | Polyclonal | Rabbit | C-Type Lectin Domain Family 10 Member A / CD301 (CLEC10A) | Unconjugated | ELISA, WB, IHC | 337.5 | 100 µg | RUO | ||
Abbexa | CLEC10A | abx340749 | C-type lectin domain family 10 member A (CLEC10A) Antibody (FITC) | Human | Polyclonal | Rabbit | C-type lectin domain family 10 member A (CLEC10A) | FITC | 250 | 50 µl | Q8IUN9 | RUO | ||
Abbexa | CLEC10A | abx340748 | C-type lectin domain family 10 member A (CLEC10A) Antibody (HRP) | Human | Polyclonal | Rabbit | C-type lectin domain family 10 member A (CLEC10A) | HRP | ELISA | 250 | 50 µl | Q8IUN9 | RUO | |
Abbexa | CLEC10A | abx125682 | C-Type Lectin Domain Family 10 Member A / CD301 (CLEC10A) Antibody | Human | Polyclonal | Rabbit | C-Type Lectin Domain Family 10 Member A / CD301 (CLEC10A) | Unconjugated | WB | 175 | 20 µl | Q8IUN9 | RUO | |
Abbexa | CLEC10A | abx414122 | C-Type Lectin Domain Family 10 Member A / CD301 (CLEC10A) Antibody (Biotin) | Mouse | Monoclonal | Rat | C-Type Lectin Domain Family 10 Member A / CD301 (CLEC10A) | Biotin | FCM | 475 | 100 µg | RUO | ||
Abbexa | CLEC10A | abx270729 | C-Type Lectin Domain Family 10 Member A / CD301 (CLEC10A) Antibody (APC) | Mouse | Polyclonal | Rabbit | C-Type Lectin Domain Family 10 Member A / CD301 (CLEC10A) | APC | FCM | 800 | 200 tests | RUO | ||
Abbexa | CLEC10A | abx370774 | C-Type Lectin Domain Family 10 Member A / CD301 (CLEC10A) Antibody Pair | Mouse | C-Type Lectin Domain Family 10 Member A / CD301 (CLEC10A) | ELISA | 1400 | 5 × 96 tests | RUO | |||||
Abbexa | CLEC10A | abx270497 | C-Type Lectin Domain Family 10 Member A / CD301 (CLEC10A) Antibody (FITC) | Mouse | Polyclonal | Rabbit | C-Type Lectin Domain Family 10 Member A / CD301 (CLEC10A) | FITC | FCM | 575 | 200 tests | RUO | ||
Abbexa | CLEC10A | abx270199 | C-Type Lectin Domain Family 10 Member A / CD301 (CLEC10A) Antibody | Mouse | Polyclonal | Rabbit | C-Type Lectin Domain Family 10 Member A / CD301 (CLEC10A) | Unconjugated | FCM | 300 | 50 tests | RUO | ||
Abbexa | CLEC10A | abx104271 | C-Type Lectin Domain Family 10 Member A / CD301 (CLEC10A) Antibody | Mouse | Polyclonal | Rabbit | C-Type Lectin Domain Family 10 Member A / CD301 (CLEC10A) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | P49300 | RUO | |
Abbexa | CLEC10A | abx414121 | C-Type Lectin Domain Family 10 Member A / CD301 (CLEC10A) Antibody | Mouse | Monoclonal | Rat | C-Type Lectin Domain Family 10 Member A / CD301 (CLEC10A) | Unconjugated | IHC, IF/ICC, FCM | 550 | 250 µg | RUO | ||
Abbexa | CLEC10A | abx414125 | C-Type Lectin Domain Family 10 Member A / CD301 (CLEC10A) Antibody | Mouse | Monoclonal | Rat | C-Type Lectin Domain Family 10 Member A / CD301 (CLEC10A) | Unconjugated | ELISA, IHC, IF/ICC | 200 | 25 µg | RUO | ||
Abbexa | CLEC10A | abx270961 | C-Type Lectin Domain Family 10 Member A / CD301 (CLEC10A) Antibody (PE) | Mouse | Polyclonal | Rabbit | C-Type Lectin Domain Family 10 Member A / CD301 (CLEC10A) | PE | FCM | 687.5 | 200 tests | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | CLEC10A | abx693213 | Mouse C-Type Lectin Domain Family 10 Member A / CD301 (CLEC10A) Protein | Mouse | Recombinant | HEK293 cells | SDS-PAGE | 775 | 50 µg | RUO | ||
Abbexa | CLEC10A | abx680129 | Human C-Type Lectin Domain Family 10 Member A / CD301 (CLEC10A) Protein | Human | Recombinant | Insect | Unconjugated | SDS-PAGE | 225 | 2 µg | RUO | |
Abbexa | CLEC10A | abx066162 | Human C-Type Lectin Domain Family 10 Member A / CD301 (CLEC10A) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 212.5 | 10 µg | Q8IUN9 | RUO |
Abbexa | CLEC10A | abx693017 | Mouse C-Type Lectin Domain Family 10 Member A / CD301 (CLEC10A) Protein | Mouse | Recombinant | HEK293 cells | SDS-PAGE | 775 | 50 µg | RUO | ||
Abbexa | CLEC10A | abx066159 | Mouse C-Type Lectin Domain Family 10 Member A / CD301 (CLEC10A) Protein | Mouse | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 225 | 10 µg | P49300 | RUO |
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