Mouse C-Type Lectin Domain Family 10 Member A / CD301 (CLEC10A) Protein

Este producto es parte de CLEC10A - C-type lectin domain containing 10A
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923€ (50 µg)

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935106861
info@markelab.com
name
Mouse C-Type Lectin Domain Family 10 Member A / CD301 (CLEC10A) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx693017
tested applications
SDS-PAGE

Description

Mouse CLEC10A Protein is a recombinant protein from Mouse produced in HEK293 Cells. A DNA sequence encoding the extracellular domain of mouse CLEC10A (NP_001191181.1) (Gln 58-Ser 305) was fused with the Fc region of human IgG1 at the N-terminus.

Documents del producto

Instrucciones
Data sheet
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Product specifications

Category
Proteins and Peptides
Immunogen Target
CLEC10A
Host
HEK293 cells
Origin
Mouse
Observed MW
Molecular Weight: 56.7 kDa
Sequence Fragment: Gln58-Ser305
Tag: N-terminal Fc tag
Validity: The validity for this protein is 12 months.
Expression
Recombinant
Purity
> 86% (SDS-PAGE)
Size 1
50 µg
Form
Tested Applications
SDS-PAGE
Buffer
Lyophilized from sterile PBS, pH 7.4.
Availability
Shipped within 5-15 working days.
Storage
Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
NCBI Accession
NP_001191181.1
Alias
C-type lectin domain family 10 member A,HML,MGL,HML2,CD301,CLECSF13,CLECSF14,C-type lectin superfamily member 14,Macrophage lectin 2
Background
Protein CLEC10A
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

CLEC10A (C-type lectin domain containing 10A), also known as CD301 or MGL (Macrophage Galactose-Type Lectin), is a transmembrane protein in the C-type lectin receptor (CLR) family primarily expressed on antigen-presenting cells such as dendritic cells, macrophages, and certain monocytes. CLEC10A is part of the innate immune system, specializing in recognizing carbohydrate structures on the surfaces of cells and pathogens. Specifically, it binds to terminal galactose and N-acetylgalactosamine (GalNAc) residues, making it essential for identifying certain pathogens and interacting with glycoproteins on cellular surfaces. CLEC10A’s specificity for galactose-containing glycans allows it to function in immune surveillance, pathogen clearance, and immunomodulation, making it a focal point in immune-related research. Its expression on dendritic cells and macrophages positions it to play a key role in the innate immune system's interactions with the adaptive immune response, particularly in tissue immune environments. CLEC10A’s involvement in recognizing glycosylated antigens has implications for disease processes, including infections, cancer, and autoimmune conditions.
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