Family main features
CD320, also known as the CD320 molecule or the transcobalamin receptor, is a cell surface protein involved in the transport and cellular uptake of vitamin B12 (cobalamin). It plays a pivotal role in maintaining cellular cobalamin levels, essential for critical cellular functions such as DNA synthesis, red blood cell formation, and neurological health. CD320 facilitates the binding and endocytosis of transcobalamin (TC)-bound vitamin B12 into cells, thus supporting cellular metabolism and growth. It is expressed in various tissues, with heightened expression in tissues requiring high levels of cobalamin, such as the liver, kidneys, and certain regions of the brain.
This protein is particularly important in hematopoiesis and nervous system function due to its role in maintaining adequate levels of cobalamin for the function of enzymes involved in methylation and mitochondrial DNA synthesis. CD320 is also gaining attention in immunology, as it has been identified on B cells and other antigen-presenting cells (APCs), suggesting a broader immunomodulatory role. Mutations or deficiencies in CD320-mediated cobalamin uptake are associated with metabolic and hematological disorders, highlighting its essential function in human health.
The CD320 protein is a type I transmembrane glycoprotein, meaning it has a single transmembrane domain anchoring it to the cell membrane, with the majority of its structure located extracellularly. The main structural domains of CD320 include:
Extracellular Domain:
Transmembrane Domain:
Cytoplasmic Tail:
CD320 belongs to the low-density lipoprotein receptor (LDLR) family, specifically due to its possession of LDLa domains. These domains are a hallmark of proteins that interact with and internalize various ligands, including lipoproteins, nutrients, and other essential molecules.
CD320 does not have multiple subtypes but is highly conserved across species, suggesting a critical role in cellular functions requiring cobalamin. Its expression levels vary across different tissue types, with particularly high expression in the liver, kidney, and immune tissues, reflecting its importance in nutrient uptake and metabolism in these regions.
The primary function of CD320 is to mediate the cellular uptake of cobalamin, a critical function for cells requiring high levels of this vitamin for metabolic activities. CD320 facilitates this through several mechanisms:
Cobalamin Uptake and Cellular Metabolism:
Role in Hematopoiesis:
Immune Modulation and B-Cell Function:
Neuronal Health:
CD320 dysfunction or deficiency is associated with several clinical conditions, predominantly stemming from cobalamin deficiency and its resultant metabolic and neurological impacts:
Megaloblastic Anemia and Cobalamin Deficiency:
Neurological Impairment:
Inherited CD320 Mutations:
Therapeutic Target in Cobalamin Disorders:
CD320 is a critical transmembrane receptor in the LDL receptor family, facilitating the uptake of cobalamin for essential cellular functions. Structurally, it is a type I membrane protein featuring two extracellular LDLa domains, a single transmembrane segment, and a short cytoplasmic tail, enabling it to bind and internalize the transcobalamin-cobalamin complex into cells. Its expression across various tissues, especially those with high cobalamin demands, underscores its significance in maintaining cellular metabolism, hematopoiesis, and neurological health.
Functionally, CD320 supports DNA synthesis, cell division, and neuronal maintenance by ensuring adequate cellular levels of cobalamin. It has a key role in hematopoiesis, immune modulation, and nervous system health. Clinically, mutations or deficiencies in CD320 can lead to megaloblastic anemia, neurological impairments, and other symptoms related to cobalamin deficiency. CD320 is thus not only essential for maintaining cellular cobalamin levels but also a potential therapeutic target in managing metabolic and hematological disorders linked to cobalamin deficiency.
CD320 molecule (CD320)
Transcobalamin receptor ,8D6,8D6A,TCBLR,TCN2R,TCII-R,sCD320,8D6 antigen,8D6 antigen
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, Primary Antibodies, ELISA Kits) relacionados con CD320 - CD320 molecule
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Esta página contiene 17 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
FineTest | CD320 | EH7192 | Human CD320 ELISA Kit | human | Busacar en las instrucciones | Sandwich ELISA, Double Antibody | 0.156-10ng/ml | 96T | Q9NPF0 | RUO | ||
Abbexa | CD320 | abx505763 | Human CD320 antigen (CD320) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q9NPF0 | RUO | ||
Abbexa | CD320 | abx505764 | Mouse CD320 antigen (CD320) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q9Z1P5 | RUO | ||
Abbexa | CD320 | abx505765 | Rat Cluster of Differentiation 320 (CD320) ELISA Kit | Rat | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q5HZW5 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
FineTest | CD320 | FNab01466 | anti- CD320 antibody | human | polyclonal | Rabbit | CD320 molecule | IgG | Unconjugated | ELISA, WB, IHC | 100µg | Q9NPF0 | RUO | |
Abbexa | CD320 | abx321191 | Cluster of Differentiation 320 (CD320) Antibody | Human | Polyclonal | Rabbit | Cluster of Differentiation 320 (CD320) | Unconjugated | ELISA, IHC | 250 | 50 µl | Q9NPF0 | RUO | |
Abbexa | CD320 | abx111476 | Cluster of Differentiation 320 (CD320) Antibody | Human | Polyclonal | Rabbit | Cluster of Differentiation 320 (CD320) | Unconjugated | ELISA, WB, IHC | 612.5 | 100 µl | Q9NPF0 | RUO | |
Abbexa | CD320 | abx027232 | Cluster of Differentiation 320 (CD320) Antibody | Human | Polyclonal | Rabbit | Cluster of Differentiation 320 (CD320) | Unconjugated | ELISA, WB | 281.25 | 80 µl | Q9NPF0 | RUO | |
Abbexa | CD320 | abx231466 | Cluster of Differentiation 320 (CD320) Antibody | Human | Polyclonal | Rabbit | Cluster of Differentiation 320 (CD320) | Unconjugated | ELISA, WB, IHC | 350 | 100 µg | Q9NPF0 | RUO | |
Abbexa | CD320 | abx123610 | Cluster of Differentiation 320 (CD320) Antibody | Human | Polyclonal | Rabbit | Cluster of Differentiation 320 (CD320) | Unconjugated | WB | 175 | 20 µl | Q9NPF0 | RUO | |
Abbexa | CD320 | abx130266 | Cluster of Differentiation 320 (CD320) Antibody | Rat | Polyclonal | Rabbit | Cluster of Differentiation 320 (CD320) | Unconjugated | WB, IHC, IF/ICC | 275 | 100 µl | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | CD320 | abx167578 | Rat Cluster Of Differentiation 320 (CD320) Protein | Rat | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 212.5 | 10 µg | Q5HZW5 | RUO |
Abbexa | CD320 | abx655908 | Human Cluster Of Differentiation 320 (CD320) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 212.5 | 10 µg | Q9NPF0 | RUO |
Abbexa | CD320 | abx655907 | Mouse Cluster Of Differentiation 320 (CD320) Protein | Mouse | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 212.5 | 10 µg | Q9Z1P5 | RUO |
Abbexa | CD320 | abx691298 | Human CD320 Antigen (CD320) Protein | Human | Recombinant | Human | SDS-PAGE | 225 | 10 µg | Q9NPF0 | RUO | |
Abbexa | CD320 | abx680221 | Human Cluster of Differentiation 320 (CD320) Protein | Human | Recombinant | Insect | Unconjugated | SDS-PAGE | 225 | 2 µg | RUO | |
Abbexa | CD320 | abx690008 | Human CD320 Antigen (CD320) Protein | Human | Recombinant | Human | SDS-PAGE | 225 | 10 µg | Q9NPF0 | RUO |
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