Human CD320 antigen (CD320) ELISA Kit

Este producto es parte de CD320 - CD320 molecule
Human CD320 antigen (CD320) ELISA Kit
715€ (96 tests)

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Name
Human CD320 antigen (CD320) ELISA Kit
Category
ELISA Kits
Provider
Abbexa
Reference
abx505763
Tested Applications
ELISA

Description

Human CD320 antigen (CD320) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human CD320 antigen (CD320) concentrations in tissue homogenates, cell lysates and other biological fluids.

Documentos del producto

Instrucciones
Data sheet
Descargar

Especificaciones del producto

Category
ELISA Kits
Immunogen Target
CD320 antigen (CD320)
Reactivity
Human
Detection Method
Colorimetric
Assay Data
Quantitative
Test Range
0.156 ng/ml - 10 ng/ml
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Size 1
96 tests
Form
Standard Form: Lyophilized
Tested Applications
ELISA
Sample Type
Tissue homogenates, cell lysates and other biological fluids.
Availability
Shipped within 5-15 working days.
Storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
Dry Ice
No
UniProt ID
Q9NPF0
Alias
Transcobalamin receptor ,8D6,8D6A,TCBLR,TCN2R,TCII-R,sCD320,8D6 antigen,8D6 antigen
Background
Elisa Kits for: CD320
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout.

Background

CD320, also known as the CD320 molecule or the transcobalamin receptor, is a cell surface protein involved in the transport and cellular uptake of vitamin B12 (cobalamin). It plays a pivotal role in maintaining cellular cobalamin levels, essential for critical cellular functions such as DNA synthesis, red blood cell formation, and neurological health. CD320 facilitates the binding and endocytosis of transcobalamin (TC)-bound vitamin B12 into cells, thus supporting cellular metabolism and growth. It is expressed in various tissues, with heightened expression in tissues requiring high levels of cobalamin, such as the liver, kidneys, and certain regions of the brain. This protein is particularly important in hematopoiesis and nervous system function due to its role in maintaining adequate levels of cobalamin for the function of enzymes involved in methylation and mitochondrial DNA synthesis. CD320 is also gaining attention in immunology, as it has been identified on B cells and other antigen-presenting cells (APCs), suggesting a broader immunomodulatory role. Mutations or deficiencies in CD320-mediated cobalamin uptake are associated with metabolic and hematological disorders, highlighting its essential function in human health.

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