Human CD320 Antigen (CD320) Protein
247€ (10 µg)
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935106861
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name
Human CD320 Antigen (CD320) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx691298
tested applications
SDS-PAGE
Description
Human CD320 Antigen Protein is a recombinant protein from Human produced in HEK293 Cells. Recombinant CD320 Protein is produced by our Mammalian expression system and the target gene encoding Ser36-Val231 is expressed with a Fc tag at the C-terminus.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Human CD320 Antigen (CD320) |
| Host | HEK293 cells |
| Origin | Human |
| Observed MW | Molecular Weight: Calculated MW: 47.3 kDa Observed MW: 58 kDa, 60 kDa Sequence Fragment: Ser36-Val231 Tag: C-terminal Fc tag |
| Expression | Recombinant |
| Purity | > 85% (SDS-PAGE) |
| Purification | 0.2 µm filtered prior to lyophilization. |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Form | Lyophilized Reconstitute in sterile water to a stock concentration of 0.25 mg/ml. Do not vortex. |
| Tested Applications | SDS-PAGE |
| Buffer | Prior to lyophilization: 20 mM Tris-HCl, 150 mM NaCl, pH 8.0. |
| Availability | Shipped within 5-15 working days. |
| Storage | Store lyophilized between -20 °C and -80 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9NPF0 |
| Alias | Transcobalamin receptor ,8D6,8D6A,TCBLR,TCN2R,TCII-R,sCD320,8D6 antigen,8D6 antigen |
| Background | Protein CD320 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
CD320, also known as the CD320 molecule or the transcobalamin receptor, is a cell surface protein involved in the transport and cellular uptake of vitamin B12 (cobalamin). It plays a pivotal role in maintaining cellular cobalamin levels, essential for critical cellular functions such as DNA synthesis, red blood cell formation, and neurological health. CD320 facilitates the binding and endocytosis of transcobalamin (TC)-bound vitamin B12 into cells, thus supporting cellular metabolism and growth. It is expressed in various tissues, with heightened expression in tissues requiring high levels of cobalamin, such as the liver, kidneys, and certain regions of the brain. This protein is particularly important in hematopoiesis and nervous system function due to its role in maintaining adequate levels of cobalamin for the function of enzymes involved in methylation and mitochondrial DNA synthesis. CD320 is also gaining attention in immunology, as it has been identified on B cells and other antigen-presenting cells (APCs), suggesting a broader immunomodulatory role. Mutations or deficiencies in CD320-mediated cobalamin uptake are associated with metabolic and hematological disorders, highlighting its essential function in human health.
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CD320, also known as 8D6, 8D6A or TCblR, is a single-pass type I membrane protein containing 2 LDL-receptor class A domains. Expressed abundantly on follicular dendritic cells (FDCs), CD320 has been shown to enhance proliferation of germinal center (GC) B cells. It is the receptor for cellular uptake of transcobalamin-bound cobalamin. Defects in CD320 are the cause of methylmalonic aciduria type TCblR (MMATC). CD320 has a calculated molecular mass of 29 kDa. This antibody detects bands at 50-55 kDa and 60-70 kDa, probably caused by extensive complex glycosylation.
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