Family main features
CD302, also known as the CD302 molecule or CLEC13A, is a protein within the C-type lectin receptor (CLR) family and plays a role in the immune system. Expressed predominantly on dendritic cells, monocytes, macrophages, and granulocytes, CD302 is a transmembrane receptor that is thought to facilitate immune cell migration, adhesion, and pathogen recognition. Structurally, CD302 shares characteristics with other C-type lectins, specifically with a C-type lectin-like domain (CTLD) that mediates interactions with carbohydrates on microbial surfaces. As a receptor, CD302 is involved in various processes including endocytosis and phagocytosis, making it an essential component of immune cell function and pathogen defense mechanisms.
CD302’s expression across various immune cell types suggests it plays a broad role in both innate and adaptive immune responses, particularly in antigen-presenting cells (APCs) like macrophages and dendritic cells. Given its cell-surface localization and involvement in binding to carbohydrate structures, CD302 is of significant interest in studies related to host-pathogen interactions, immune surveillance, and potentially in autoimmune and inflammatory diseases.
The structure of CD302 is integral to its function as a receptor in the immune system:
Extracellular C-type Lectin-like Domain (CTLD):
Transmembrane Domain:
Cytoplasmic Tail:
Glycosylation Sites:
CD302 belongs to the C-type lectin receptor (CLR) family, specifically classified as CLEC13A within the group of C-type lectin-like receptors. Unlike some C-type lectins that have multiple subtypes or isoforms, CD302 is primarily expressed as a single type without significant variations. However, it often interacts with other receptors within the CLR family, such as Dectin-1 and Dectin-2, which may amplify or modulate its functions.
CD302 has several key functions that underscore its biological importance:
Endocytosis and Phagocytosis:
Pathogen Recognition:
Cell Adhesion and Migration:
Role in Tumor Immunity:
Given its functions in pathogen recognition and immune modulation, CD302 is implicated in several clinical contexts:
Infectious Diseases:
Cancer:
Autoimmune and Inflammatory Disorders:
Hematological Disorders:
CD302 is a type I transmembrane protein within the C-type lectin receptor family, predominantly expressed on antigen-presenting cells, such as dendritic cells, macrophages, and certain granulocytes. Its structure features an extracellular C-type lectin-like domain, which is responsible for binding carbohydrate residues on pathogen surfaces and glycosylated antigens. This carbohydrate-binding capability is integral to CD302’s role in immune cell functions, including endocytosis, pathogen recognition, cell adhesion, and migration.
Biologically, CD302 functions in the immune system as a receptor for glycan structures, aiding in pathogen detection and immune cell trafficking. Clinically, CD302 has significant implications in infectious diseases, where it assists in pathogen recognition and clearance, and in cancer, where it may influence immune surveillance of tumor cells. Its role in autoimmune and inflammatory conditions is also under investigation, as CD302’s interactions with self-antigens could affect immune homeostasis.
CD302’s potential as a therapeutic target lies in its roles in immune surveillance and cell migration. In cancer, modulating CD302 function could enhance anti-tumor immunity, while in infectious diseases, enhancing its pathogen-binding capability could improve host defenses. Research into CD302’s structure and function continues to reveal its significance in health and disease, with emerging studies likely to provide further insights into its applications in immunotherapy and disease management.
CD302 molecule (CD302)
C-type lectin domain family 13 member A,DCL1,DCL-1,BIMLEC,CLEC13A,C-type lectin BIMLEC,DEC205-associated C-type lectin 1Cdmolecule/CD302
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, ELISA Kits, Primary Antibodies) relacionados con CD302 - CD302 molecule
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Esta página contiene 13 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | CD302 | abx505758 | Human CD302 antigen (CD302) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q8IX05 | RUO | ||
Abbexa | CD302 | abx505759 | Mouse CD302 antigen (CD302) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q9DCG2 | RUO | ||
Abbexa | CD302 | abx505761 | Rat C-Type Lectin Domain Family 13 Member A (CD302) ELISA Kit | Rat | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q5FVR3 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | CD302 | abx323692 | C-Type Lectin Domain Family 13 Member A (CD302) Antibody | Human | Polyclonal | Rabbit | C-Type Lectin Domain Family 13 Member A (CD302) | Unconjugated | ELISA, WB | 187.5 | 50 µg | Q8IX05 | RUO | |
Abbexa | CD302 | abx308683 | C-Type Lectin Domain Family 13 Member A (CD302) Antibody (FITC) | Human | Polyclonal | Rabbit | C-Type Lectin Domain Family 13 Member A (CD302) | FITC | 162.5 | 20 µg | Q8IX05 | RUO | ||
Abbexa | CD302 | abx308681 | C-Type Lectin Domain Family 13 Member A (CD302) Antibody | Human | Polyclonal | Rabbit | C-Type Lectin Domain Family 13 Member A (CD302) | Unconjugated | ELISA | 162.5 | 20 µg | Q8IX05 | RUO | |
Abbexa | CD302 | abx308684 | C-Type Lectin Domain Family 13 Member A (CD302) Antibody (Biotin) | Human | Polyclonal | Rabbit | C-Type Lectin Domain Family 13 Member A (CD302) | Biotin | ELISA | 162.5 | 20 µg | Q8IX05 | RUO | |
Abbexa | CD302 | abx308682 | C-Type Lectin Domain Family 13 Member A (CD302) Antibody (HRP) | Human | Polyclonal | Rabbit | C-Type Lectin Domain Family 13 Member A (CD302) | HRP | ELISA | 162.5 | 20 µg | Q8IX05 | RUO | |
Abbexa | CD302 | abx013932 | C-Type Lectin Domain Family 13 Member A (CD302) Antibody | Human | Polyclonal | Rabbit | C-Type Lectin Domain Family 13 Member A (CD302) | Unconjugated | WB, IHC | 43.75 | 10 µg | Q8IX05 | RUO | |
Abbexa | CD302 | abx328834 | C-Type Lectin Domain Family 13 Member A (CD302) Antibody | Human | Polyclonal | Rabbit | C-Type Lectin Domain Family 13 Member A (CD302) | Unconjugated | ELISA, WB, IHC | 187.5 | 50 µg | Q8IX05 | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | CD302 | abx690906 | Rat C-Type Lectin Domain Family 13 Member A (CD302) Protein | Rat | Recombinant | HEK293 cells | SDS-PAGE | 962.5 | 100 µg | RUO | ||
Abbexa | CD302 | abx691283 | Mouse C-Type Lectin Domain Family 13 Member A (CD302) Protein | Mouse | Recombinant | HEK293 cells | SDS-PAGE | 962.5 | 100 µg | Q9DCG2-2 | RUO | |
Abbexa | CD302 | abx692537 | Mouse C-Type Lectin Domain Family 13 Member A (CD302) Protein | Mouse | Recombinant | HEK293 cells | SDS-PAGE | 962.5 | 100 µg | Q9DCG2-2 | RUO |
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