Family main features
Bone morphogenetic protein receptor type 1B (BMPR1B) is a serine/threonine kinase receptor that plays a central role in mediating the effects of bone morphogenetic proteins (BMPs), which are part of the transforming growth factor-beta (TGF-β) superfamily. BMPs are critical regulators of cell growth, differentiation, development, and tissue repair. BMPR1B specifically binds BMP ligands, initiating signaling pathways that drive cellular responses crucial for skeletal development, cartilage formation, and neural differentiation. Unlike BMPR1A, which has broader expression and interacts with a range of BMPs, BMPR1B expression is more restricted, and it is particularly important in cartilage development and chondrogenesis.
BMPR1B is a transmembrane receptor with a highly specialized structure that is crucial for its function in signal transduction. It consists of three main domains:
Extracellular Ligand-Binding Domain:
Transmembrane Domain:
Intracellular Serine/Threonine Kinase Domain:
BMPR1B is part of the type I BMP receptor family and has unique features that distinguish it from BMPR1A:
BMPR1B works in tandem with type II BMP receptors (such as BMPR2, ActRIIA, and ActRIIB) to form receptor complexes, allowing full activation and signal propagation in response to BMP binding.
The biological functions of BMPR1B are centered around its roles in skeletal and cartilage development, and it is critical in mediating cellular responses in tissues that undergo structural development and repair:
Cartilage and Bone Development:
Joint Formation:
Neural Development:
Tissue Repair and Regeneration:
Dysregulation or mutation in BMPR1B can lead to various developmental disorders and skeletal diseases:
Brachydactyly Type A2 (BDA2):
Acromesomelic Dysplasia (AMD):
Osteoarthritis (OA):
Potential Role in Cancer:
BMPR1B (bone morphogenetic protein receptor type 1B) is a type I receptor critical for mediating BMP signaling, particularly in skeletal and cartilage development. Its unique extracellular ligand-binding domain allows BMPR1B to specifically bind BMPs, and its intracellular kinase domain transduces signals that regulate gene expression through SMAD proteins. BMPR1B is essential for chondrogenesis, joint formation, and tissue regeneration, influencing mesenchymal cell differentiation into chondrocytes and other specialized cell types.
Mutations in BMPR1B can lead to skeletal and joint malformations, such as brachydactyly type A2 and acromesomelic dysplasia, underscoring its importance in cartilage and bone growth. Altered BMPR1B activity has also been implicated in osteoarthritis and may play a role in specific cancer contexts. BMPR1B’s critical function in development and repair makes it a significant focus for research in developmental biology, regenerative medicine, and potential therapeutic applications in skeletal disorders and joint diseases.
bone morphogenetic protein receptor type 1B (BMPR1B)
BMP type-1B receptor,BMPR-1BALK6,AMD3,AMDD,BDA2,ALK-6,BDA1D,CDw293
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, CLIA Kits, Primary Antibodies, ELISA Kits) relacionados con BMPR1B - bone morphogenetic protein receptor type 1B
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
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Abbexa | BMPR1B | abx491951 | Human Bone Morphogenetic Protein Receptor 1B (BMPR1B) CLIA Kit | Human | Tissue homogenates, cell lysates and other biological fluids. | Sandwich | 0.312 ng/ml - 20 ng/ml | < 0.117 ng/ml | 812.5 | 96 tests | RUO | |
Abbexa | BMPR1B | abx150827 | Human Bone Morphogenetic Protein Receptor 1B (BMPR1B) ELISA Kit | Human | Tissue homogenates,Other biological fluids | Sandwich | 0.312 ng/ml - 20 ng/ml | < 0.12 ng/ml | 618.75 | 96 tests | RUO | |
Abbexa | BMPR1B | abx511389 | Mouse Bone Morphogenetic Protein Receptor 1B (BMPR1B) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.083 ng/ml | 687.5 | 96 tests | O35607 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | BMPR1B | abx028698 | Bone Morphogenetic Protein Receptor 1B (Bmpr1b) Antibody | Human | Polyclonal | Rabbit | Bone Morphogenetic Protein Receptor 1B (Bmpr1b) | Unconjugated | ELISA, WB | 250 | 80 µl | P36898 | RUO | |
Abbexa | BMPR1B | abx036912 | Bone Morphogenetic Protein Receptor 1B (BMPR1B) Antibody | Human | Polyclonal | Rabbit | Bone Morphogenetic Protein Receptor 1B (BMPR1B) | Unconjugated | ELISA, WB, IHC | 337.5 | 100 µg | RUO | ||
Abbexa | BMPR1B | abx315606 | Bone Morphogenetic Protein Receptor 1B (BMPR1B) Antibody (FITC) | Human | Polyclonal | Rabbit | Bone Morphogenetic Protein Receptor 1B (BMPR1B) | FITC | 162.5 | 20 µg | O00238 | RUO | ||
Abbexa | BMPR1B | abx031363 | Bone Morphogenetic Protein Receptor 1B (BMPR1B) Antibody | Human | Polyclonal | Rabbit | Bone Morphogenetic Protein Receptor 1B (BMPR1B) | Unconjugated | ELISA, WB | 281.25 | 80 µl | O00238 | RUO | |
Abbexa | BMPR1B | abx026569 | Bone Morphogenetic Protein Receptor 1B (BMPR1B) Antibody | Human | Polyclonal | Rabbit | Bone Morphogenetic Protein Receptor 1B (BMPR1B) | Unconjugated | ELISA, WB, IHC | 281.25 | 80 µl | O00238 | RUO | |
Abbexa | BMPR1B | abx315605 | Bone Morphogenetic Protein Receptor 1B (BMPR1B) Antibody (HRP) | Human | Polyclonal | Rabbit | Bone Morphogenetic Protein Receptor 1B (BMPR1B) | HRP | ELISA | 162.5 | 20 µg | O00238 | RUO | |
Abbexa | BMPR1B | abx122169 | Bone Morphogenetic Protein Receptor 1B (BMPR1B) Antibody | Human | Polyclonal | Rabbit | Bone Morphogenetic Protein Receptor 1B (BMPR1B) | Unconjugated | ELISA, WB, IHC | 337.5 | 100 µg | RUO | ||
Abbexa | BMPR1B | abx315607 | Bone Morphogenetic Protein Receptor 1B (BMPR1B) Antibody (Biotin) | Human | Polyclonal | Rabbit | Bone Morphogenetic Protein Receptor 1B (BMPR1B) | Biotin | ELISA | 162.5 | 20 µg | O00238 | RUO | |
Abbexa | BMPR1B | abx325357 | Bone Morphogenetic Protein Receptor 1B (BMPR1B) Antibody | Human | Polyclonal | Rabbit | Bone Morphogenetic Protein Receptor 1B (BMPR1B) | Unconjugated | ELISA, IHC | 187.5 | 50 µg | O00238 | RUO | |
Abbexa | BMPR1B | abx212606 | Bone Morphogenetic Protein Receptor 1B (BMPR1B) Antibody | Human | Polyclonal | Rabbit | Bone Morphogenetic Protein Receptor 1B (BMPR1B) | Unconjugated | ELISA, IHC | 250 | 50 µl | O00238 | RUO | |
Abbexa | BMPR1B | abx031362 | Bone Morphogenetic Protein Receptor 1B (BMPR1B) Antibody | Human | Polyclonal | Rabbit | Bone Morphogenetic Protein Receptor 1B (BMPR1B) | Unconjugated | ELISA, WB | 281.25 | 80 µl | O00238 | RUO | |
Abbexa | BMPR1B | abx212607 | Bone Morphogenetic Protein Receptor 1B (BMPR1B) Antibody | Human | Polyclonal | Rabbit | Bone Morphogenetic Protein Receptor 1B (BMPR1B) | Unconjugated | ELISA, IHC | 250 | 50 µl | O00238 | RUO | |
Abbexa | BMPR1B | abx117175 | Bone Morphogenetic Protein Receptor 1B (BMPR1B) Antibody | Human | Polyclonal | Rabbit | Bone Morphogenetic Protein Receptor 1B (BMPR1B) | Unconjugated | ELISA, WB, IHC | 450 | 100 µl | O00238 | RUO | |
Abbexa | BMPR1B | abx001630 | Bone Morphogenetic Protein Receptor 1B (BMPR1B) Antibody | Human | Polyclonal | Rabbit | Bone Morphogenetic Protein Receptor 1B (BMPR1B) | Unconjugated | WB, IHC, IF/ICC | 175 | 20 µl | O00238 | RUO | |
Abbexa | BMPR1B | abx318856 | Bone Morphogenetic Protein Receptor 1B (BMPR1B) Antibody | Human | Polyclonal | Rabbit | Bone Morphogenetic Protein Receptor 1B (BMPR1B) | Unconjugated | ELISA, WB, IHC, IF/ICC | 162.5 | 20 µg | O00238 | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | BMPR1B | abx690976 | Mouse Bone Morphogenetic Protein Receptor 1B (BMPR1B) Protein | Mouse | Recombinant | HEK293 cells | SDS-PAGE | 1050 | 100 µg | P36898 | RUO | |
Abbexa | BMPR1B | abx652698 | Human Bone Morphogenetic Protein Receptor 1B (BMPR1B) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 1800 | 1 mg | RUO |
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