Family main features
CD300A, also known as immune receptor expressed by myeloid cells (IREM-1) or leukocyte mono-immunoglobulin-like receptor 8 (LMIR8), is a member of the CD300 family of immunoreceptors. This molecule plays a significant role in the regulation of immune responses. It is encoded by the CD300A gene located on the human chromosome 17. CD300A is primarily expressed on the surface of myeloid cells, including monocytes, macrophages, dendritic cells, and some subsets of lymphocytes.
The CD300 family consists of several members, each contributing to the regulation of immune cell functions. CD300A, in particular, is recognized for its inhibitory functions, helping to maintain immune homeostasis and preventing overactivation that could lead to autoimmunity.
CD300A is a type I transmembrane protein characterized by an extracellular domain, a transmembrane region, and a cytoplasmic tail:
CD300A belongs to the CD300 family, which includes both activating and inhibitory receptors. The classification within this family is based on the presence of ITIMs or immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic tails.
Other members of the CD300 family include CD300B (activating receptor), CD300C, CD300D, CD300E, CD300F, and CD300G, each contributing differently to immune regulation.
CD300A is primarily involved in the negative regulation of immune responses. Its functions and biological significance include:
CD300A is implicated in various clinical conditions, primarily due to its role in immune regulation:
CD300A, a member of the CD300 family, is a key inhibitory receptor on myeloid cells. Its structure includes an extracellular Ig-like domain, a transmembrane region, and a cytoplasmic tail with ITIMs. CD300A plays crucial roles in regulating immune responses, maintaining homeostasis, and modulating inflammation and phagocytosis. It is involved in various clinical conditions, including autoimmune diseases, infections, allergies, and cancer. Understanding the precise mechanisms of CD300A's function and its interactions with other immune regulatory molecules is essential for developing targeted therapies that modulate immune responses in various diseases.
CD300a molecule (CD300A)
CMRF35H,IGSF12,CMRF-35-H9,CMRF35-H9,IRC1/IRC2,Immunoglobulin superfamily member 12
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, Primary Antibodies, ELISA Kits) relacionados con CD300A molecule
Se muestran ordenados por categorías para poder comparar cómodamente sus características principales. Esta tabla, que contiene un enlace con la ficha de cada producto, es exportable a Excel.
Esta página contiene 19 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | CD300A | abx507335 | Human CMRF35-like molecule 8 (CD300A) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q9UGN4 | RUO | ||
Abbexa | CD300A | abx507336 | Mouse CMRF35-like molecule 8 (CD300A) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q6SJQ0 | RUO | ||
Abbexa | CD300A | abx507337 | Rat CMRF35-Like Molecule 8 (CD300A) ELISA Kit | Rat | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | A2TGX5 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | CD300A | abx415164 | CMRF35-Like Molecule 8 (CD300A) Antibody (FITC) | Human | Monoclonal | Mouse | CMRF35-Like Molecule 8 (CD300A) | FITC | FCM | 400 | 100 µg | Q9UGN4 | RUO | |
Abbexa | CD300A | abx146214 | CMRF35-Like Molecule 8 (CD300A) Antibody | Human | Polyclonal | Rabbit | CMRF35-Like Molecule 8 (CD300A) | Unconjugated | ELISA, WB | 337.5 | 100 µg | RUO | ||
Abbexa | CD300A | abx414508 | CMRF35-Like Molecule 8 (CD300A) Antibody | Human | Monoclonal | Mouse | CMRF35-Like Molecule 8 (CD300A) | Unconjugated | WB, FCM | 337.5 | 100 µg | Q9UGN4 | RUO | |
Abbexa | CD300A | abx139997 | CMRF35-Like Molecule 8 (CD300A) Antibody | Human | Monoclonal | Mouse | CMRF35-Like Molecule 8 (CD300A) | Unconjugated | WB, FCM | 300 | 0.1 mg | Q9UGN4 | RUO | |
Abbexa | CD300A | abx415163 | CMRF35-Like Molecule 8 (CD300A) Antibody | Human | Monoclonal | Mouse | CMRF35-Like Molecule 8 (CD300A) | Unconjugated | FCM | 462.5 | 200 µg | Q9UGN4 | RUO | |
Abbexa | CD300A | abx321205 | CMRF35-Like Molecule 8 (CD300A) Antibody | Human | Polyclonal | Rabbit | CMRF35-Like Molecule 8 (CD300A) | Unconjugated | ELISA, IHC | 250 | 50 µl | Q9UGN4 | RUO | |
Abbexa | CD300A | abx135925 | CMRF35-Like Molecule 8 (CD300A) Antibody | Human | Polyclonal | Rabbit | CMRF35-Like Molecule 8 (CD300A) | Unconjugated | WB | 175 | 20 µl | Q9UGN4 | RUO | |
Abbexa | CD300A | abx139998 | CMRF35-Like Molecule 8 (CD300A) Antibody (PE) | Human | Monoclonal | Mouse | CMRF35-Like Molecule 8 (CD300A) | PE | FCM | 400 | 100 tests | Q9UGN4 | RUO | |
Abbexa | CD300A | abx140479 | CMRF35-Like Molecule 8 (CD300A) Antibody (APC) | Human | Monoclonal | Mouse | CMRF35-Like Molecule 8 (CD300A) | APC | FCM | 400 | 100 tests | Q9UGN4 | RUO | |
Abbexa | CD300A | abx415165 | CMRF35-Like Molecule 8 (CD300A) Antibody (PE) | Human | Monoclonal | Mouse | CMRF35-Like Molecule 8 (CD300A) | PE | FCM | 487.5 | 100 tests | Q9UGN4 | RUO | |
Abbexa | CD300A | abx322634 | CMRF35-Like Molecule 8 (CD300A) Antibody | Human | Polyclonal | Rabbit | CMRF35-Like Molecule 8 (CD300A) | Unconjugated | ELISA, WB, IHC | 250 | 50 µl | Q9UGN4 | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | CD300A | abx691350 | Mouse CMRF35-Like Molecule 8 (CD300A) Protein | Mouse | Recombinant | Human | SDS-PAGE | 225 | 10 µg | Q6SJQ0 | RUO | |
Abbexa | CD300A | abx691310 | Human CMRF35-Like Molecule 8 (CD300A) Protein | Human | Recombinant | HEK293 cells | SDS-PAGE | 837.5 | 100 µg | Q9UGN4-1 | RUO | |
Abbexa | CD300A | abx692574 | Human CMRF35-Like Molecule 8 (CD300A) Protein | Human | Recombinant | HEK293 cells | SDS-PAGE | 487.5 | 50 µg | Q9UGN4-1 | RUO | |
Abbexa | CD300A | abx262674 | CMRF35-Like Molecule 8 (CD300A) Protein | Recombinant | Unconjugated | SDS-PAGE | 225 | 2 µg | Q9UGN4 | RUO | ||
Abbexa | CD300A | abx691243 | Mouse CMRF35-Like Molecule 8 (CD300A) Protein | Mouse | Recombinant | HEK293 cells | SDS-PAGE | 487.5 | 50 µg | Q6SJQ0-1 | RUO |
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