Family main features
AXL receptor tyrosine kinase (AXL) is a member of the TAM (Tyro3, AXL, and MERTK) receptor tyrosine kinase family. This family of receptors is characterized by their roles in cell survival, proliferation, migration, and immune regulation. AXL was first identified as a transforming gene in chronic myeloid leukemia, and since then, it has been implicated in a variety of physiological and pathological processes, including cancer, fibrosis, and immune response modulation.
AXL and its ligands are widely expressed in various tissues, including the cardiovascular, immune, and nervous systems. The primary ligand for AXL is growth arrest-specific 6 (Gas6), a vitamin K-dependent protein that mediates the receptor's activation. Binding of Gas6 to AXL triggers a cascade of downstream signaling events that influence cellular behaviors and fate decisions.
The AXL protein is composed of several distinct domains that facilitate its diverse functions:
AXL is one of three members of the TAM receptor family. The other two members are Tyro3 and MERTK. While all three receptors share similar structural features and overlapping functions, they also exhibit distinct expression patterns and physiological roles.
AXL plays a multifaceted role in various biological processes:
The dysregulation of AXL is associated with several diseases, particularly cancer and fibrotic disorders:
AXL receptor tyrosine kinase is a pivotal regulator of cell survival, proliferation, migration, and immune responses. Structurally characterized by its extracellular Ig-like and FNIII domains, a transmembrane segment, and an intracellular kinase domain, AXL orchestrates a variety of signaling pathways that influence cellular behaviors. Its involvement in cancer progression, fibrotic diseases, and immune regulation underscores its significance in health and disease. Targeting AXL with specific inhibitors presents a promising therapeutic strategy for treating cancers and other conditions associated with AXL dysregulation. Understanding the precise mechanisms and contexts of AXL function continues to be an area of active research, with significant implications for developing novel clinical interventions.
AXL receptor tyrosine kinase (AXL)
ARK,UFO,AXL3,JTK11,Tyro7,AXL oncogene,Tyrosine-protein kinase receptor UFO
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, CLIA Kits, Primary Antibodies, ELISA Kits) relacionados con AXL receptor tyrosine kinase
Se muestran ordenados por categorías para poder comparar cómodamente sus características principales. Esta tabla, que contiene un enlace con la ficha de cada producto, es exportable a Excel.
Esta página contiene 28 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
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FineTest | AXL | EH6594 | Human AXL(Tyrosine-protein kinase receptor UFO) ELISA Kit | human | Busacar en las instrucciones | Sandwich ELISA, Double Antibody | 0.156-10ng/ml | 96T | P30530 | RUO | ||
Abbexa | AXL | abx495899 | Human Tyrosine-Protein Kinase Receptor UFO (AXL) CLIA Kit | Human | Serum, plasma, tissue homogenates and other biological fluids. | Sandwich | 0.312 ng/ml - 20 ng/ml | < 0.112 ng/ml | 812.5 | 96 tests | RUO | |
Abbexa | AXL | abx258647 | Human Tyrosine-Protein Kinase Receptor UFO (AXL) ELISA Kit | Human | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich | 0.312 ng/ml - 20 ng/ml | < 0.12 ng/ml | 687.5 | 96 tests | P30530 | RUO |
Abbexa | AXL | abx520098 | Mouse Tyrosine-Protein Kinase Receptor UFO (AXL) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 31.2 pg/ml - 2000 pg/ml | 537.5 | 96 tests | Q00993 | RUO | |
Abbexa | AXL | abx155242 | Rat Tyrosine-Protein Kinase Receptor UFO (AXL) ELISA Kit | Rat | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 2.4 ng/ml - 150 ng/ml | < 0.8 ng/ml | 737.5 | 96 tests | RUO | |
Abbexa | AXL | abx495900 | Rat Tyrosine-Protein Kinase Receptor UFO (AXL) CLIA Kit | Rat | Serum, plasma and other biological fluids. | Sandwich | 2.34 ng/ml - 150 ng/ml | < 0.9 ng/ml | 868.75 | 96 tests | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
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FineTest | AXL | FNab00754 | anti- AXL antibody | human | polyclonal | Rabbit | AXL receptor tyrosine kinase | IgG | Unconjugated | ELISA, WB, IP, FC | 100µg | P30530 | RUO | |
Abbexa | AXL | abx033506 | Tyrosine-Protein Kinase Receptor UFO (AXL) Antibody | Human | Polyclonal | Rabbit | Tyrosine-Protein Kinase Receptor UFO (AXL) | Unconjugated | ELISA, WB, IHC | 281.25 | 80 µl | P30530 | RUO | |
Abbexa | AXL | abx036741 | Tyrosine-Protein Kinase Receptor UFO (AXL) Antibody | Human | Polyclonal | Rabbit | Tyrosine-Protein Kinase Receptor UFO (AXL) | Unconjugated | ELISA, WB | 337.5 | 100 µg | RUO | ||
Abbexa | AXL | abx334374 | Tyrosine-Protein Kinase Receptor UFO (AXL) Antibody | Human | Polyclonal | Rabbit | Tyrosine-Protein Kinase Receptor UFO (AXL) | Unconjugated | ELISA, IHC, IF/ICC | 162.5 | 20 µg | P30530 | RUO | |
Abbexa | AXL | abx028539 | Tyrosine-Protein Kinase Receptor UFO (AXL) Antibody | Human | Polyclonal | Rabbit | Tyrosine-Protein Kinase Receptor UFO (AXL) | Unconjugated | ELISA, WB | 250 | 80 µl | Q00993 | RUO | |
Abbexa | AXL | abx338143 | Tyrosine-Protein Kinase Receptor UFO (AXL) Antibody (HRP) | Human | Polyclonal | Rabbit | Tyrosine-Protein Kinase Receptor UFO (AXL) | HRP | ELISA | 162.5 | 20 µg | P30530 | RUO | |
Abbexa | AXL | abx338144 | Tyrosine-Protein Kinase Receptor UFO (AXL) Antibody (FITC) | Human | Polyclonal | Rabbit | Tyrosine-Protein Kinase Receptor UFO (AXL) | FITC | 162.5 | 20 µg | P30530 | RUO | ||
Abbexa | AXL | abx033505 | Tyrosine-Protein Kinase Receptor UFO (AXL) Antibody | Human | Polyclonal | Rabbit | Tyrosine-Protein Kinase Receptor UFO (AXL) | Unconjugated | ELISA, WB, IHC, FCM | 250 | 80 µl | P30530 | RUO | |
Abbexa | AXL | abx033507 | Tyrosine-Protein Kinase Receptor UFO (AXL) Antibody | Human | Polyclonal | Rabbit | Tyrosine-Protein Kinase Receptor UFO (AXL) | Unconjugated | ELISA, WB, IHC, FCM | 281.25 | 80 µl | P30530 | RUO | |
Abbexa | AXL | abx338145 | Tyrosine-Protein Kinase Receptor UFO (AXL) Antibody (Biotin) | Human | Polyclonal | Rabbit | Tyrosine-Protein Kinase Receptor UFO (AXL) | Biotin | ELISA | 162.5 | 20 µg | P30530 | RUO | |
Abbexa | AXL | abx011796 | Tyrosine-Protein Kinase Receptor UFO (AXL) Antibody | Human | Monoclonal | Mouse | Tyrosine-Protein Kinase Receptor UFO (AXL) | Unconjugated | ELISA | 362.5 | 100 µl | P30530 | RUO | |
Abbexa | AXL | abx015709 | Tyrosine-Protein Kinase Receptor UFO (AXL) Antibody | Human | Monoclonal | Mouse | Tyrosine-Protein Kinase Receptor UFO (AXL) | Unconjugated | ELISA, IF/ICC | 362.5 | 100 µl | P30530 | RUO | |
Abbexa | AXL | abx327038 | Tyrosine-Protein Kinase Receptor UFO (AXL) Antibody | Human | Polyclonal | Rabbit | Tyrosine-Protein Kinase Receptor UFO (AXL) | Unconjugated | ELISA, WB | 187.5 | 50 µg | P30530 | RUO | |
Abbexa | AXL | abx328449 | Tyrosine-Protein Kinase Receptor UFO Phospho-Tyr691 (AXL pY691) Antibody | Human | Polyclonal | Rabbit | Tyrosine-Protein Kinase Receptor UFO Phospho-Tyr691 (AXL pY691) | Unconjugated | ELISA, WB, IHC | 187.5 | 50 µg | P30530 | RUO | |
Abbexa | AXL | abx326400 | Tyrosine-Protein Kinase Receptor UFO (AXL) Antibody | Human | Polyclonal | Rabbit | Tyrosine-Protein Kinase Receptor UFO (AXL) | Unconjugated | ELISA, IHC | 187.5 | 50 µg | P30530 | RUO | |
Abbexa | AXL | abx230754 | Tyrosine-Protein Kinase Receptor UFO (AXL) Antibody | Human | Polyclonal | Rabbit | Tyrosine-Protein Kinase Receptor UFO (AXL) | Unconjugated | ELISA, WB, FCM, IP | 350 | 100 µg | P30530 | RUO | |
Abbexa | AXL | abx130417 | Tyrosine-Protein Kinase Receptor UFO (AXL) Antibody | Rat | Polyclonal | Rabbit | Tyrosine-Protein Kinase Receptor UFO (AXL) | Unconjugated | WB, IHC, IF/ICC | 300 | 100 µl | Q8VIA0 | RUO | |
Abbexa | AXL | abx171380 | Tyrosine-Protein Kinase Receptor UFO (AXL) Antibody | Rat | Monoclonal | Mouse | Tyrosine-Protein Kinase Receptor UFO (AXL) | Unconjugated | WB, IHC, IF/ICC | 937.5 | 1 ml | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | AXL | abx168518 | Rat Tyrosine-Protein Kinase Receptor UFO (AXL) Protein | Rat | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 225 | 10 µg | RUO | |
Abbexa | AXL | abx691915 | Mouse Tyrosine-Protein Kinase Receptor UFO (AXL) Protein | Mouse | Recombinant | HEK293 cells | SDS-PAGE | 837.5 | 100 µg | RUO | ||
Abbexa | AXL | abx692066 | Human Tyrosine-Protein Kinase Receptor UFO (AXL) Protein | Human | Recombinant | HEK293 cells | SDS-PAGE | 562.5 | 100 µg | RUO | ||
Abbexa | AXL | abx692708 | Mouse Tyrosine-Protein Kinase Receptor UFO (AXL) Protein | Mouse | Recombinant | HEK293 cells | SDS-PAGE | 837.5 | 100 µg | RUO |
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