Tyrosine-Protein Kinase Receptor UFO (AXL) Antibody
292.5€ (80 µl)
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Name
Tyrosine-Protein Kinase Receptor UFO (AXL) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx033505
Tested Applications
ELISA, WB, IHC, FCM
Description
AXL, a member of the AXL/UFO subfamily of Tyr protein kinases, may function as a signal transducer between specific cell types of mesodermal origin. This Type I membrane protein has transforming potential in patients with chronic myeloproliferative disorder or chronic myelocytic leukemia. The protein contains 2 putative fibronectin type III domains and 2 putative immunoglobulin-like C2-type domains.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Tyrosine-Protein Kinase Receptor UFO (AXL) Immunogen: KLH-conjugated synthetic peptide between 13-44 amino acids from the N-terminal region of human AXL. |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000, IHC-P: 1/50 - 1/100, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 98.3 kDa |
| Purification | Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, FCM |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P30530 |
| NCBI Accession | NP_001690.2, NP_068713.2 |
| Alias | ARK,UFO,AXL3,JTK11,Tyro7,AXL oncogene,Tyrosine-protein kinase receptor UFO |
| Background | Antibody anti-AXL |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
AXL receptor tyrosine kinase (AXL) is a member of the TAM (Tyro3, AXL, and MERTK) receptor tyrosine kinase family. This family of receptors is characterized by their roles in cell survival, proliferation, migration, and immune regulation. AXL was first identified as a transforming gene in chronic myeloid leukemia, and since then, it has been implicated in a variety of physiological and pathological processes, including cancer, fibrosis, and immune response modulation. AXL and its ligands are widely expressed in various tissues, including the cardiovascular, immune, and nervous systems. The primary ligand for AXL is growth arrest-specific 6 (Gas6), a vitamin K-dependent protein that mediates the receptor's activation. Binding of Gas6 to AXL triggers a cascade of downstream signaling events that influence cellular behaviors and fate decisions.
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