Tyrosine-Protein Kinase Receptor UFO (AXL) Antibody
383.5€ (100 µl)
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Name
Tyrosine-Protein Kinase Receptor UFO (AXL) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx015709
Tested Applications
ELISA, IF/ICC
Description
AXL: AXL receptor tyrosine kinase, also known as UFO, JTK11.Entrez Protein NP_001690.It is a member of the receptor tyrosine kinase subfamily.Although it is similar to other receptor tyrosine kinases, this protein represents a unique structure of the extracellular region that juxtaposes IgL and FNIII repeats.It transduces signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein growth-arrest-specific gene 6.It is involved in the stimulation of cell proliferation and can also mediate cell aggregation by homophilic binding.Alternatively spliced transcript variants encoding different isoforms have been identified.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Tyrosine-Protein Kinase Receptor UFO (AXL) Immunogen: Purified recombinant extracellular fragment of human AXL fused with hIgGFc tag expressed in HEK293 cell line. |
| Host | Mouse |
| Reactivity | Human |
| Assay Type | Concentration: Not determined. |
| Recommended Dilution | ELISA: 1/10000, IF/ICC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Observed MW | 97.4 kDa |
| Purification | Unpurified ascites. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, IF/ICC |
| Buffer | Ascitic fluid containing 0.03% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P30530 |
| Gene ID | 558 |
| OMIM | 109135 |
| Alias | ARK,UFO,AXL3,JTK11,Tyro7,AXL oncogene,Tyrosine-protein kinase receptor UFO |
| Background | Antibody anti-AXL |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
AXL receptor tyrosine kinase (AXL) is a member of the TAM (Tyro3, AXL, and MERTK) receptor tyrosine kinase family. This family of receptors is characterized by their roles in cell survival, proliferation, migration, and immune regulation. AXL was first identified as a transforming gene in chronic myeloid leukemia, and since then, it has been implicated in a variety of physiological and pathological processes, including cancer, fibrosis, and immune response modulation. AXL and its ligands are widely expressed in various tissues, including the cardiovascular, immune, and nervous systems. The primary ligand for AXL is growth arrest-specific 6 (Gas6), a vitamin K-dependent protein that mediates the receptor's activation. Binding of Gas6 to AXL triggers a cascade of downstream signaling events that influence cellular behaviors and fate decisions.
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