Mouse Apoptosis Inducing Factor (AIF) CLIA Kit
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Description
Mouse Apoptosis Inducing Factor (AIF) Chemiluminescent Immunoassay (CLIA) Kit is a Chemiluminescent Immunoassay (CLIA) kit against Apoptosis Inducing Factor (AIF).
Documents del producto
Product specifications
| Category | CLIA Kits |
| Immunogen Target | Apoptosis Inducing Factor (AIF) |
| Reactivity | Mouse |
| Detection Method | Chemiluminescent |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 6.25 pg/ml - 400 pg/ml |
| Sensitivity | 3.75 pg/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | CLIA |
| Sample Type | Serum, plasma and other biological fluids. |
| Availability | Shipped within 5-12 working days. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| Alias | AIFM1,AIF,PDCD8 |
| Background | CLIA Kits AIF |
| Status | RUO |
| Note | The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
Apoptosis Inducing Factor (AIF) is a mitochondrial flavoprotein that plays a dual role in cellular processes, including apoptosis and redox homeostasis. Under normal conditions, AIF resides in the mitochondria, where it participates in oxidative phosphorylation and protects against reactive oxygen species (ROS). During apoptotic signaling, AIF translocates from the mitochondria to the nucleus, where it triggers chromatin condensation and large-scale DNA fragmentation in a caspase-independent manner. This makes AIF a key mediator of programmed cell death in response to mitochondrial dysfunction or oxidative stress. Dysregulation of AIF is implicated in neurodegenerative diseases, such as Parkinson's and Alzheimer's, where mitochondrial dysfunction and cell death contribute to disease progression. Additionally, AIF mutations have been linked to mitochondrial encephalomyopathy and other metabolic disorders. Targeting AIF-related pathways is being explored as a therapeutic strategy for conditions involving excessive cell death or mitochondrial dysfunction.
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This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6, which results in a severe mitochondrial encephalomyopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 10.
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