Family main features
ADAM33, also known as ADAM metallopeptidase domain 33, is a member of the ADAM family of proteins. It is primarily associated with asthma and related respiratory conditions.ADAM33 is a transmembrane protein, meaning it spans the cell membrane. It contains several distinct domains, including a metalloproteinase domain, a disintegrin domain, a cysteine-rich domain, an EGF-like domain, a transmembrane domain, and a cytoplasmic tail. These domains suggest roles in proteolysis, cell adhesion, and signaling. ADAM33 is primarily expressed in lung tissues, particularly in smooth muscle cells, fibroblasts, and airway epithelial cells. Its expression is upregulated in asthmatic individuals and has been linked to airway remodeling, a hallmark of chronic asthma.ADAM33 gene variants have been consistently associated with asthma susceptibility and severity in various populations. These genetic variations may influence ADAM33 expression levels or protein function, contributing to the pathogenesis of asthma. ADAM33 may serve as a potential biomarker for asthma diagnosis, prognosis, and treatment response.
ADAM33 has the characteristic multi-domain structure of ADAM family proteins:
ADAM33 belongs to the ADAM family and is classified as a proteolytic enzyme due to its active metalloprotease domain. It is primarily expressed as a membrane-bound protein but can also be found in a soluble form after proteolytic cleavage.
ADAM33 is involved in several critical biological functions:
ADAM33 interacts with various proteins and cellular components:
ADAM33 has significant implications in respiratory diseases, particularly asthma:
ADAM33, a member of the ADAM family, is essential for airway remodeling and respiratory health. It has a multi-domain structure, including a metalloprotease domain for proteolytic activity and a disintegrin domain for cell adhesion. ADAM33 interacts with integrins, extracellular matrix proteins, growth factors, and immune cells. Clinically, ADAM33 is significant in the context of asthma, COPD, lung cancer, and fibrotic diseases. Understanding its structure, function, interactions, and clinical implications provides valuable insights into its roles in respiratory diseases and potential as a therapeutic target.
ADAM metallopeptidase domain 33(ADAM33)
C20orf153,A Disintegrin And Metalloprotease 33 ,adam-33
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, Primary Antibodies, CLIA Kits, ELISA Kits) relacionados con ADAM33 - ADAM metallopeptidase domain 33
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Esta página contiene 13 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
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FineTest | ADAM33 | EH1834 | Human ADAM33(Disintegrin and metalloproteinase domain-containing protein 33) ELISA Kit | human | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich ELISA, Double Antibody | 78.125-5000pg/ml | 96T | Q9BZ11 | RUO | ||
Abbexa | ADAM33 | abx496119 | Human ADAM Metallopeptidase Domain 33 (ADAM33) CLIA Kit | Human | Tissue homogenates, cell lysates and other biological fluids. | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.054 ng/ml | 812.5 | 96 tests | Q9BZ11 | RUO |
Abbexa | ADAM33 | abx251145 | Human ADAM Metallopeptidase Domain 33 (ADAM33) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 78 pg/ml - 5000 pg/ml | 46.9 pg/ml | 562.5 | 96 tests | Q9BZ11 | RUO |
Abbexa | ADAM33 | abx150549 | Human ADAM Metallopeptidase Domain 33 (ADAM33) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.06 ng/ml | 687.5 | 96 tests | Q9BZ11 | RUO |
Abbexa | ADAM33 | abx571096 | Human ADAM Metallopeptidase Domain 33 (ADAM33) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 31.2 pg/ml - 2000 pg/ml | 18.8 pg/ml | 562.5 | 96 tests | Q9BZ11 | RUO |
Abbexa | ADAM33 | abx517868 | Mouse ADAM Metallopeptidase Domain 33 (ADAM33) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 78 pg/ml - 5000 pg/ml | 687.5 | 96 tests | Q923W9 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | ADAM33 | abx320583 | ADAM Metallopeptidase Domain 33 (ADAM33) Antibody | Human | Polyclonal | Rabbit | ADAM Metallopeptidase Domain 33 (ADAM33) | Unconjugated | ELISA, IHC | 237.5 | 50 µl | Q9BZ11 | RUO | |
Abbexa | ADAM33 | abx129275 | A Disintegrin And Metalloprotease 33 (ADAM33) Antibody | Human | Polyclonal | Rabbit | A Disintegrin And Metalloprotease 33 (ADAM33) | Unconjugated | WB, IHC, IF/ICC | 287.5 | 100 µl | Q9BZ11 | RUO | |
Abbexa | ADAM33 | abx321635 | ADAM Metallopeptidase Domain 33 (ADAM33) Antibody | Human | Polyclonal | Rabbit | ADAM Metallopeptidase Domain 33 (ADAM33) | Unconjugated | ELISA, WB, IHC | 237.5 | 50 µl | Q9BZ11 | RUO | |
Abbexa | ADAM33 | abx038437 | ADAM Metallopeptidase Domain 33 (ADAM33) Antibody | Human | Polyclonal | Rabbit | ADAM Metallopeptidase Domain 33 (ADAM33) | Unconjugated | ELISA, WB | 337.5 | 100 µg | RUO | ||
Abbexa | ADAM33 | abx171033 | A Disintegrin And Metalloprotease 33 (ADAM33) Antibody | Human | Monoclonal | Mouse | A Disintegrin And Metalloprotease 33 (ADAM33) | Unconjugated | WB, IHC, IF/ICC | 875 | 1 ml | RUO | ||
Abbexa | ADAM33 | abx005774 | ADAM Metallopeptidase Domain 33 (ADAM33) Antibody | Human | Polyclonal | Rabbit | ADAM Metallopeptidase Domain 33 (ADAM33) | Unconjugated | WB | 175 | 20 µl | Q9BZ11 | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | ADAM33 | abx168239 | Human A Disintegrin And Metalloprotease 33 (ADAM33) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 225 | 10 µg | RUO |
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