Human A Disintegrin And Metalloprotease 33 (ADAM33) Protein

234€ (10 µg)
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935106861
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name
Human A Disintegrin And Metalloprotease 33 (ADAM33) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx168239
tested applications
WB, SDS-PAGE
Description
ADAM33 Protein is a recombinant Human protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
Category | Proteins and Peptides |
Immunogen Target | A Disintegrin And Metalloprotease 33 (ADAM33) |
Host | E. coli |
Origin | Human |
Conjugation | Unconjugated |
Observed MW | Molecular Weight: Calculated MW: 35.3 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Lys210-Asp503 Tag: N-terminal His tag |
Expression | Recombinant |
Purity | > 90% |
Size 1 | 10 µg |
Size 2 | 50 µg |
Size 3 | 100 µg |
Size 4 | 200 µg |
Size 5 | 500 µg |
Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
Tested Applications | WB, SDS-PAGE |
Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
Availability | Shipped within 5-7 working days. |
Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
Dry Ice | No |
Alias | C20orf153,A Disintegrin And Metalloprotease 33 ,adam-33 |
Background | Protein ADAM33 |
Status | RUO |
Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
ADAM33, also known as ADAM metallopeptidase domain 33, is a member of the ADAM family of proteins. It is primarily associated with asthma and related respiratory conditions.ADAM33 is a transmembrane protein, meaning it spans the cell membrane. It contains several distinct domains, including a metalloproteinase domain, a disintegrin domain, a cysteine-rich domain, an EGF-like domain, a transmembrane domain, and a cytoplasmic tail. These domains suggest roles in proteolysis, cell adhesion, and signaling. ADAM33 is primarily expressed in lung tissues, particularly in smooth muscle cells, fibroblasts, and airway epithelial cells. Its expression is upregulated in asthmatic individuals and has been linked to airway remodeling, a hallmark of chronic asthma.ADAM33 gene variants have been consistently associated with asthma susceptibility and severity in various populations. These genetic variations may influence ADAM33 expression levels or protein function, contributing to the pathogenesis of asthma. ADAM33 may serve as a potential biomarker for asthma diagnosis, prognosis, and treatment response.
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