Family main features
Absent in melanoma 2 (AIM2) is a protein-coding gene. It's part of the AIM2-like receptor (ALR) family, which plays a crucial role in innate immunity and inflammation. AIM2 specifically functions as a cytosolic DNA sensor, detecting the presence of double-stranded DNA (dsDNA) from pathogens or damaged host cells. Activated AIM2 recruits apoptosis-associated speck-like protein containing a CARD (ASC), forming the inflamasome. This inflammasome activation leads to the cleavage and activation of caspase-1, which in turn initiates the processing and secretion of pro-inflammatory cytokines such as interleukin-1β (IL-1β) and interleukin-18 (IL-18). These cytokines play essential roles in orchestrating the immune response against infections and in regulating inflammatory processes. In addition to its role in immunity, AIM2 has been implicated in various diseases and conditions, including autoimmune disorders, inflammatory diseases, and cancer. Dysregulation of AIM2 signaling has been associated with the pathogenesis of conditions such as systemic lupus erythematosus (SLE), Crohn's disease, and certain types of cancer. In cancer, AIM2's role is complex and context-dependent. While it can exert tumor-suppressive effects by promoting cell death in response to genomic instability or viral infections, AIM2 activation has also been linked to the promotion of inflammation and tumorigenesis in certain contexts.
AIM2 (Absent in Melanoma 2) is a cytosolic DNA sensor that plays a pivotal role in the innate immune response by forming the AIM2 inflammasome. This inflammasome activates caspase-1, leading to the production of pro-inflammatory cytokines and pyroptosis. AIM2 is crucial for detecting cytosolic DNA from pathogens and damaged cells, initiating immune responses to infections and cellular stress. Dysregulation of AIM2 can lead to autoimmune diseases and impact cancer progression, making it a significant target for therapeutic research. Understanding AIM2's mechanisms and interactions is essential for developing treatments for diseases associated with inflammation and immune dysregulation.
absent in melanoma 2 (AIM2)
PYHIN4,Interferon inducible protein AIM2
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, Primary Antibodies, ELISA Kits, CLIA Kits) relacionados con AIM2 - Absent in melanoma 2
Se muestran ordenados por categorías para poder comparar cómodamente sus características principales. Esta tabla, que contiene un enlace con la ficha de cada producto, es exportable a Excel.
Esta página contiene 28 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
Contacta con nosotros en info@markelab.com, si necesitas mas informacion o alguna aclaracion. Te garantizamos respuesta en menos de 24 h.
provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
FineTest | AIM2 | EH2125 | Human AIM2(Interferon-inducible protein AIM2) ELISA Kit | human | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich ELISA, Double Antibody | 0.156-10ng/ml | 96T | O14862 | RUO | ||
Abbexa | AIM2 | abx150516 | Human Absent In Melanoma 2 (AIM2) ELISA Kit | Human | Serum,Plasma,Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.07 ng/ml | 687.5 | 96 tests | O14862 | RUO |
Abbexa | AIM2 | abx196415 | Human Absent In Melanoma 2 (AIM2) CLIA Kit | Human | Serum, plasma and other biological fluids. | Sandwich | 31.2 pg/ml - 2000 pg/ml | 18.8 pg/ml | 618.75 | 96 tests | RUO | |
Abbexa | AIM2 | abx251459 | Human Absent In Melanoma 2 (AIM2) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | 0.1 ng/ml | 556.25 | 96 tests | O14862 | RUO |
Abbexa | AIM2 | abx495148 | Human Absent In Melanoma 2 (AIM2) CLIA Kit | Human | Serum, plasma, tissue homogenates, cell lysates and other biological fluids. | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.063 ng/ml | 812.5 | 96 tests | O14862 | RUO |
Abbexa | AIM2 | abx519536 | Mouse Absent In Melanoma 2 (AIM2) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 1.25 ng/ml - 80 ng/ml | < 0.625 ng/ml | 687.5 | 96 tests | Q91VJ1 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
FineTest | AIM2 | FNab00238 | anti- AIM2 antibody | human | polyclonal | Rabbit | absent in melanoma 2 | IgG | Unconjugated | ELISA, WB, IHC | 100µg | O14862 | RUO | |
Abbexa | AIM2 | abx432297 | Absent In Melanoma 2 (AIM2) Antibody | Human | Polyclonal | Goat | Absent In Melanoma 2 (AIM2) | Unconjugated | P-ELISA, WB, IHC | 387.5 | 200 µl | RUO | ||
Abbexa | AIM2 | abx171046 | Absent In Melanoma 2 (AIM2) Antibody | Human | Monoclonal | Mouse | Absent In Melanoma 2 (AIM2) | Unconjugated | WB, IHC, IF/ICC | 787.5 | 1 ml | RUO | ||
Abbexa | AIM2 | abx230238 | Absent In Melanoma 2 (AIM2) Antibody | Human | Polyclonal | Rabbit | Absent In Melanoma 2 (AIM2) | Unconjugated | ELISA, WB, IHC | 350 | 100 µg | O14862 | RUO | |
Abbexa | AIM2 | abx013903 | Absent In Melanoma 2 (AIM2) Antibody | Human | Polyclonal | Rabbit | Absent In Melanoma 2 (AIM2) | Unconjugated | ELISA, WB | 43.75 | 10 µg | O14862 | RUO | |
Abbexa | AIM2 | abx128104 | Absent In Melanoma 2 (AIM2) Antibody | Human | Polyclonal | Rabbit | Absent In Melanoma 2 (AIM2) | Unconjugated | WB, IHC, IF/ICC | 275 | 100 µl | O14862 | RUO | |
Abbexa | AIM2 | abx314042 | Absent In Melanoma 2 (AIM2) Antibody (FITC) | Human | Polyclonal | Rabbit | Absent In Melanoma 2 (AIM2) | FITC | 162.5 | 20 µg | O14862 | RUO | ||
Abbexa | AIM2 | abx314043 | Absent In Melanoma 2 (AIM2) Antibody (Biotin) | Human | Polyclonal | Rabbit | Absent In Melanoma 2 (AIM2) | Biotin | ELISA | 162.5 | 20 µg | O14862 | RUO | |
Abbexa | AIM2 | abx314041 | Absent In Melanoma 2 (AIM2) Antibody (HRP) | Human | Polyclonal | Rabbit | Absent In Melanoma 2 (AIM2) | HRP | ELISA | 162.5 | 20 µg | O14862 | RUO | |
Abbexa | AIM2 | abx324905 | Absent In Melanoma 2 (AIM2) Antibody | Human | Polyclonal | Rabbit | Absent In Melanoma 2 (AIM2) | Unconjugated | ELISA, WB, IHC, IF/ICC | 187.5 | 50 µg | O14862 | RUO | |
Abbexa | AIM2 | abx339813 | Absent In Melanoma 2 (AIM2) Antibody | Human | Polyclonal | Rabbit | Absent In Melanoma 2 (AIM2) | Unconjugated | ELISA, IHC | 250 | 50 µl | O14862 | RUO | |
Abbexa | AIM2 | abx224381 | Absent In Melanoma 2 (AIM2) Antibody | Human | Monoclonal | Mouse | Absent In Melanoma 2 (AIM2) | Unconjugated | ELISA, WB, IF/ICC | 362.5 | 100 µl | O14862 | RUO | |
Abbexa | AIM2 | abx037494 | Absent In Melanoma 2 (AIM2) Antibody | Human | Polyclonal | Rabbit | Absent In Melanoma 2 (AIM2) | Unconjugated | ELISA, WB, IHC | 337.5 | 100 µg | RUO | ||
Abbexa | AIM2 | abx037495 | Absent In Melanoma 2 (AIM2) Antibody | Human | Polyclonal | Rabbit | Absent In Melanoma 2 (AIM2) | Unconjugated | ELISA, WB, IHC | 337.5 | 100 µg | RUO | ||
Abbexa | AIM2 | abx110744 | Absent In Melanoma 2 (AIM2) Antibody | Human | Polyclonal | Rabbit | Absent In Melanoma 2 (AIM2) | Unconjugated | ELISA, WB | 612.5 | 100 µl | O14862 | RUO | |
Abbexa | AIM2 | abx224162 | Absent In Melanoma 2 (AIM2) Antibody | Human | Monoclonal | Mouse | Absent In Melanoma 2 (AIM2) | ELISA, IF/ICC, FCM | 362.5 | 100 µl | O14862 | RUO | ||
Abbexa | AIM2 | abx432296 | Absent In Melanoma 2 (AIM2) Antibody | Human | Polyclonal | Goat | Absent In Melanoma 2 (AIM2) | Unconjugated | P-ELISA, WB | 387.5 | 200 µl | RUO | ||
Abbexa | AIM2 | abx034902 | Absent In Melanoma 2 (AIM2) Antibody | Human | Monoclonal | Mouse | Absent In Melanoma 2 (AIM2) | Unconjugated | ELISA, WB | 250 | 80 µl | O14862 | RUO | |
Abbexa | AIM2 | abx302437 | Absent In Melanoma 2 (AIM2) Antibody | Human | Polyclonal | Rabbit | Absent In Melanoma 2 (AIM2) | Unconjugated | ELISA, WB, IHC, IF/ICC | 162.5 | 20 µg | O14862 | RUO | |
Abbexa | AIM2 | abx002396 | Absent In Melanoma 2 (AIM2) Antibody | Human | Polyclonal | Rabbit | Absent In Melanoma 2 (AIM2) | Unconjugated | WB, IF/ICC | 175 | 20 µl | O14862 | RUO | |
Abbexa | AIM2 | abx431942 | Absent In Melanoma 2 (Aim2) Antibody | Mouse | Polyclonal | Goat | Absent In Melanoma 2 (Aim2) | Unconjugated | P-ELISA | 250 | 200 µl | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | AIM2 | abx166889 | Human Absent In Melanoma 2 (AIM2) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 225 | 10 µg | RUO |
Te recomendamos que si no encuentras lo que buscas, utilices el buscador, refinando la búsqueda según tu criterio y usando Alias, o bien contacta con nosotros.