Human Absent In Melanoma 2 (AIM2) CLIA Kit

Product specifications

CLIA Kits

Absent In Melanoma 2 (AIM2)

Human

Chemiluminescent

Quantitative

Sandwich

31.2 pg/ml - 2000 pg/ml

18.8 pg/ml

Optimal dilutions/concentrations should be determined by the end user.

96 tests

Lyophilized

CLIA

Serum, plasma and other biological fluids.

Shipped within 5-12 working days.

 Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.

No

PYHIN4

CLIA Kits AIM2

RUO

The validity for this kit is 6 months.   This product is for research use only.   The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments.   Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

Descripción

Absent in melanoma 2 (AIM2) is a protein-coding gene. It's part of the AIM2-like receptor (ALR) family, which plays a crucial role in innate immunity and inflammation. AIM2 specifically functions as a cytosolic DNA sensor, detecting the presence of double-stranded DNA (dsDNA) from pathogens or damaged host cells. Activated AIM2 recruits apoptosis-associated speck-like protein containing a CARD (ASC), forming the inflamasome. This inflammasome activation leads to the cleavage and activation of caspase-1, which in turn initiates the processing and secretion of pro-inflammatory cytokines such as interleukin-1β (IL-1β) and interleukin-18 (IL-18). These cytokines play essential roles in orchestrating the immune response against infections and in regulating inflammatory processes. In addition to its role in immunity, AIM2 has been implicated in various diseases and conditions, including autoimmune disorders, inflammatory diseases, and cancer. Dysregulation of AIM2 signaling has been associated with the pathogenesis of conditions such as systemic lupus erythematosus (SLE), Crohn's disease, and certain types of cancer. In cancer, AIM2's role is complex and context-dependent. While it can exert tumor-suppressive effects by promoting cell death in response to genomic instability or viral infections, AIM2 activation has also been linked to the promotion of inflammation and tumorigenesis in certain contexts.

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