Human AIM2 (Interferon-inducible protein AIM2) ELISA Kit
Contáctenos para saber el precio
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Human AIM2 (Interferon-inducible protein AIM2) ELISA Kit
Category
ELISA Kits
Provider
FineTest
Reference
EH2125
Tested Applications
ELISA
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | ELISA Kits |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | 4 hours |
| Assay Type | Sandwich ELISA, Double Antibody |
| Test Range | 0.156-10ng/ml |
| Sensitivity | 0.094ng/ml |
| Size 1 | 96T |
| Tested Applications | ELISA |
| Sample Type | Serum, Plasma, Cell Culture Supernatant, cell or tissue lysate, Other liquid samples |
| Availability | Shipped within 10-14 working days. |
| Storage | 2-8 °C for 12 months |
| UniProt ID | O14862 |
| Alias | PYHIN4 |
| Background | Elisa kits for AIM2 |
| Status | RUO |
Background
Absent in melanoma 2 (AIM2) is a protein-coding gene. It's part of the AIM2-like receptor (ALR) family, which plays a crucial role in innate immunity and inflammation. AIM2 specifically functions as a cytosolic DNA sensor, detecting the presence of double-stranded DNA (dsDNA) from pathogens or damaged host cells. Activated AIM2 recruits apoptosis-associated speck-like protein containing a CARD (ASC), forming the inflamasome. This inflammasome activation leads to the cleavage and activation of caspase-1, which in turn initiates the processing and secretion of pro-inflammatory cytokines such as interleukin-1β (IL-1β) and interleukin-18 (IL-18). These cytokines play essential roles in orchestrating the immune response against infections and in regulating inflammatory processes. In addition to its role in immunity, AIM2 has been implicated in various diseases and conditions, including autoimmune disorders, inflammatory diseases, and cancer. Dysregulation of AIM2 signaling has been associated with the pathogenesis of conditions such as systemic lupus erythematosus (SLE), Crohn's disease, and certain types of cancer. In cancer, AIM2's role is complex and context-dependent. While it can exert tumor-suppressive effects by promoting cell death in response to genomic instability or viral infections, AIM2 activation has also been linked to the promotion of inflammation and tumorigenesis in certain contexts.
Productos relacionados
Absent In Melanoma 2 (AIM2) Antibody
AIM2 Antibody is a Rabbit Polyclonal antibody against AIM2. AIM2 is a member of the IFI20X /IFI16 family. It plays a put…
Ver producto
Absent In Melanoma 2 (AIM2) Antibody
Rabbit polyclonal antibody against AIM2 protein. Immunogen region is Internal.…
Ver producto
Absent In Melanoma 2 (AIM2) Antibody
Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity.…
Ver producto