Human Absent In Melanoma 2 (AIM2) Protein

Documentos del producto

Especificaciones del producto

Proteins and Peptides

Absent In Melanoma 2 (AIM2)

E. coli

Activity: Not tested
Sequence Fragment: Met1-Thr343
Tag: N-terminal His tag

Human

Unconjugated

Calculated MW: 43.7 kDa  Observed MW (SDS-PAGE): 44 kDa

Recombinant

> 97%

10 µg

50 µg

100 µg

200 µg

500 µg

Lyophilized

WB, SDS-PAGE

Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300.

Shipped within 5-7 working days.

Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles.

No

PYHIN4

Protein AIM2

RUO

THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Concentration: Prior to lyophilization: 200 µg/ml

Background

Absent in melanoma 2 (AIM2) is a protein-coding gene. It's part of the AIM2-like receptor (ALR) family, which plays a crucial role in innate immunity and inflammation. AIM2 specifically functions as a cytosolic DNA sensor, detecting the presence of double-stranded DNA (dsDNA) from pathogens or damaged host cells. Activated AIM2 recruits apoptosis-associated speck-like protein containing a CARD (ASC), forming the inflamasome. This inflammasome activation leads to the cleavage and activation of caspase-1, which in turn initiates the processing and secretion of pro-inflammatory cytokines such as interleukin-1β (IL-1β) and interleukin-18 (IL-18). These cytokines play essential roles in orchestrating the immune response against infections and in regulating inflammatory processes. In addition to its role in immunity, AIM2 has been implicated in various diseases and conditions, including autoimmune disorders, inflammatory diseases, and cancer. Dysregulation of AIM2 signaling has been associated with the pathogenesis of conditions such as systemic lupus erythematosus (SLE), Crohn's disease, and certain types of cancer. In cancer, AIM2's role is complex and context-dependent. While it can exert tumor-suppressive effects by promoting cell death in response to genomic instability or viral infections, AIM2 activation has also been linked to the promotion of inflammation and tumorigenesis in certain contexts.

Productos relacionados

Absent In Melanoma 2 (AIM2) Antibody

AIM2 Antibody is a Rabbit Polyclonal antibody against AIM2. AIM2 is a member of the IFI20X /IFI16 family. It plays a put…

Ver producto

Absent In Melanoma 2 (AIM2) Antibody

Rabbit polyclonal antibody against AIM2 protein. Immunogen region is Internal.…

Ver producto

Absent In Melanoma 2 (AIM2) Antibody

Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity.…

Ver producto