Uracil Nucleotide/Cysteinyl Leukotriene Receptor (GPR17) Antibody
292.5€ (80 µl)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Uracil Nucleotide/Cysteinyl Leukotriene Receptor (GPR17) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx034541
tested applications
ELISA, WB, IHC, FCM
Description
Members of the G protein coupled receptor (GPCR) superfamily contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. The organization of the GPR17 gene differs from that of many other GPCRs in that the open reading frame is distributed on 2 exons; an additional exon contains the 5 prime untranslated region. Human GPR17 is expressed as 2.3 and 6.3 kb mRNAs exclusively in brain. The 2 transcripts appear to represent alternatively polyadenylated variants. Based on protein sequence homology and the conservation of certain key residues, GPR17 appears to be closely related to the P2Y family of GPCRs. There are two nemed isoforms.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Uracil Nucleotide/Cysteinyl Leukotriene Receptor (GPR17) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000, IHC-P: 1/50 - 1/100, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, FCM |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q13304 |
| Alias | GPR17,P2Y-like receptor,UDP/CysLT receptor,R12,uracil nucleotide/cysteinyl leukotriene receptor |
| Background | Antibody anti-GPR17 |
| Status | RUO |
Descripción
GPR17 is a G protein-coupled receptor involved in several physiological processes, including the regulation of myelination, neurotransmitter release, and inflammation. GPR17 has been identified as a receptor that is expressed in oligodendrocyte precursor cells and plays a role in myelin formation in the central nervous system. GPR17 is activated by both endogenous ligands, such as uracil nucleotides, and can also respond to purines like adenosine. Upon activation, GPR17 primarily couples to Gi and Gq proteins, leading to intracellular signaling that influences cellular processes such as differentiation and migration. Dysregulation of GPR17 has been linked to neurodegenerative diseases, including multiple sclerosis, where it may impact myelin repair and regeneration. Investigating GPR17 signaling could provide new therapeutic strategies for neurodegenerative disorders and conditions that involve impaired tissue repair.
Related Products
GPR17 antibody
Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes(CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia.
Ver Producto
Uracil Nucleotide/Cysteinyl Leukotriene Receptor (GPR17) Antibody
GPR17 Antibody is a Rabbit Polyclonal antibody against GPR17.
Ver Producto
Uracil Nucleotide/Cysteinyl Leukotriene Receptor (GPR17) Antibody
Rabbit polyclonal antibody against GPR17 protein. Immunogen region is Internal.
Ver Producto