GPR17 antibody
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935106861
info@markelab.com
name
GPR17 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab03600
tested applications
ELISA, WB
Description
Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes(CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | G protein-coupled receptor 17 (GPR17) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:2000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 50 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q13304 |
| Gene ID | 2840 |
| Alias | GPR17,P2Y-like receptor,UDP/CysLT receptor,R12,uracil nucleotide/cysteinyl leukotriene receptor |
| Background | Antibody anti-GPR17 |
| Status | RUO |
| Note | Mol. Weight 50 kDa |
Descripción
GPR17 is a G protein-coupled receptor involved in several physiological processes, including the regulation of myelination, neurotransmitter release, and inflammation. GPR17 has been identified as a receptor that is expressed in oligodendrocyte precursor cells and plays a role in myelin formation in the central nervous system. GPR17 is activated by both endogenous ligands, such as uracil nucleotides, and can also respond to purines like adenosine. Upon activation, GPR17 primarily couples to Gi and Gq proteins, leading to intracellular signaling that influences cellular processes such as differentiation and migration. Dysregulation of GPR17 has been linked to neurodegenerative diseases, including multiple sclerosis, where it may impact myelin repair and regeneration. Investigating GPR17 signaling could provide new therapeutic strategies for neurodegenerative disorders and conditions that involve impaired tissue repair.
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