Uracil Nucleotide/Cysteinyl Leukotriene Receptor (GPR17) Antibody
52€ (10 µg)
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935106861
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name
Uracil Nucleotide/Cysteinyl Leukotriene Receptor (GPR17) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx015322
tested applications
ELISA, WB
Description
Rabbit polyclonal antibody against GPR17 protein. Immunogen region is Internal.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Uracil Nucleotide/Cysteinyl Leukotriene Receptor (GPR17) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/500 - 1/3000, ELISA: 1/5000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 300 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q13304 |
| Alias | GPR17,P2Y-like receptor,UDP/CysLT receptor,R12,uracil nucleotide/cysteinyl leukotriene receptor |
| Background | Antibody anti-GPR17 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
GPR17 is a G protein-coupled receptor involved in several physiological processes, including the regulation of myelination, neurotransmitter release, and inflammation. GPR17 has been identified as a receptor that is expressed in oligodendrocyte precursor cells and plays a role in myelin formation in the central nervous system. GPR17 is activated by both endogenous ligands, such as uracil nucleotides, and can also respond to purines like adenosine. Upon activation, GPR17 primarily couples to Gi and Gq proteins, leading to intracellular signaling that influences cellular processes such as differentiation and migration. Dysregulation of GPR17 has been linked to neurodegenerative diseases, including multiple sclerosis, where it may impact myelin repair and regeneration. Investigating GPR17 signaling could provide new therapeutic strategies for neurodegenerative disorders and conditions that involve impaired tissue repair.
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