UniQ PINP RIA

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935106861

info@markelab.com

Precio

Precio a consultar

proveedor

Aidian

reference

67034

Tested Applications

RIA

reactivity

human

status

CE Marked

clonality

Descripción

UniQ PINP RIA is a quantitative radioimmunoassay designed for the measurement of the concentration of intact aminoterminal propeptide of type I procollagen, an indicator of osteoblastic activity, in human serum. The test is intended to be used as an aid in the management of postmenopausal osteoporosis


UniQ PINP RIA es un radioinmunoensayo cuantitativo diseñado para medir la concentración del propéptido aminoterminal intacto de tipo I de procolágeno, un indicador de la actividad osteoblástica, en suero humano. La prueba está destinada a ser utilizada como ayuda en el manejo de la osteoporosis posmenopáusica.

Background

PINP - aminoterminal propeptide of type I procollagen - is a specific type I collagen metabolite which is liberated into the blood stream during the formation of new bone. Its concentration is directly related to the rate of bone turnover. In metabolic bone diseases such as osteoporosis, PINP is a sensitive indicator for identifying patients with a high rate of bone turnover and, consequently, at high risk of fracture. PINP is a useful parameter for monitoring the effectiveness of anti-resorptive and anabolic treatment.


PINP, el propeptido aminoterminal del colágeno tipo I, es un metabolito específico del colágeno tipo I que se libera en el torrente sanguíneo durante la formación de nuevo hueso. Su concentración está directamente relacionada con la tasa de recambio óseo. En enfermedades metabólicas del hueso como la osteoporosis, el PINP es un indicador sensible para identificar a pacientes con una alta tasa de recambio óseo y, en consecuencia, con un alto riesgo de fractura. El PINP es un parámetro útil para monitorear la eficacia del tratamiento anti-resortivo y anabólico.

Características del producto

category

RIA Kits


size 1

100 test


storage

2 – 8 °C


test range

5.0‒250 µg/l.


detection method

The UniQ PINP RIA kit is based on the competitive radioimmunoassay technique. A known amount of labelled PINP and an unknown amount of unlabelled PINP in the sample compete for a limited number of high affinity binding sites on the polyclonal rabbit anti-PINP antibody. A second antibody, directed against rabbit IgG and coated to kaolin particles, is used to separate the antibody-bound PINP from free PINP. The radioactivity of the bound tracer antigen is measured in a gamma counter. The amount of labelled PINP in the sample tube is inversely proportional to the amount of PINP in the sample. The concentrations in unknown samples are obtained from a calibration curve, which is based on the concurrent testing of the UniQ PINP RIA calibrators that contain 0 to 250 µg/l PINP.


assay data

2.7 % cross-reactivity with small monomeric degradation products (col1), no cross-reactivity with PIIINP


availability

Inmediate


dry ice

No


note

50 µl serum


reseach area

Colágeno


status

CE Marked


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