UBX Domain-Containing Protein 6 (UBXN6) Antibody
292.5€ (80 µl)
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935106861
info@markelab.com
name
UBX Domain-Containing Protein 6 (UBXN6) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx032404
tested applications
ELISA, WB, IHC
Description
UBXN6 acts in a complex with VCP and cooperates with USP7 in promoting MDM2 deubiquitination and stabilization. UBXN6 is MDM2 stabilization leads to MDM2-dependent TP53 degradation.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | UBX Domain-Containing Protein 6 (UBXN6) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1/2000, IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9BZV1 |
| Alias | UBXD1,UBXDC2,UBX domain-containing protein 1 |
| Background | Antibody anti-UBXN6 |
| Status | RUO |
Descripción
UBX domain protein 6 (UBXN6) is a p97/VCP-interacting protein that functions as a key regulator of protein homeostasis by participating in proteasome and autophagy pathways UBXN6 facilitates the extraction and degradation of ubiquitinated misfolded proteins during endoplasmic reticulum-associated degradation (ERAD), playing a vital role in cellular quality control processes It also modulates autophagy by linking p97 to lysosomal pathways for the clearance of protein aggregates Studies show that UBXN6 is involved in cellular stress responses, particularly under proteotoxic conditions where protein turnover mechanisms are critical Dysregulation of UBXN6 leads to protein aggregation and cellular dysfunction, contributing to neurodegenerative diseases such as Parkinson’s and Huntington’s diseases UBXN6 also plays a role in cancer, where its regulation of proteostasis supports tumor cell survival under stress conditions and influences apoptosis Its role in maintaining cellular integrity and proteasome activity highlights its importance in protein quality control and stress adaptation
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