UBX Domain-Containing Protein 1 (UBXN1) Antibody
377€ (100 µg)
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Name
UBX Domain-Containing Protein 1 (UBXN1) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx239214
Tested Applications
ELISA, WB
Description
UBXN1 Antibody is a Rabbit Polyclonal against UBXN1.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: UBX Domain-Containing Protein 1 (UBXN1) Immunogen: UBX domain protein 1 |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Assay Type | Concentration: 2 mg/ml |
| Recommended Dilution | WB: 1/500 - 1/5000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Observed MW: 45 kDa |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q04323 |
| Gene ID | 51035 |
| OMIM | 616378 |
| Alias | 2B28,SAKS1,UBXD10,SAPK substrate protein 1,UBA/UBX 33.3 kDa protein |
| Background | Antibody anti-UBXN1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
UBX domain protein 1 (UBXN1) is a ubiquitin regulatory protein containing a UBX domain, which enables its interaction with p97/VCP, a key ATPase involved in protein degradation and cellular quality control UBXN1 functions as a cofactor for p97, participating in the extraction and degradation of misfolded proteins during endoplasmic reticulum-associated degradation (ERAD) It regulates protein homeostasis by linking p97 to the ubiquitin-proteasome system and autophagy pathways UBXN1 is also involved in DNA damage repair, where it regulates protein turnover at replication forks and facilitates chromatin remodeling Dysregulation of UBXN1 impairs protein clearance, contributing to neurodegenerative diseases such as Alzheimer’s and Parkinson’s, where protein aggregates accumulate in neurons Emerging studies also connect UBXN1 to cancer biology, as it influences protein turnover in tumor cells and regulates apoptosis Its role in maintaining proteostasis and cellular stress responses underscores its importance in cellular quality control mechanisms
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