Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L3 (UCHL3) Antibody
195€ (20 µl)
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935106861
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name
Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L3 (UCHL3) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx006082
tested applications
ELISA, WB
Description
UCHL3 Antibody is a Rabbit Polyclonal Antibody against UCHL3.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L3 (UCHL3) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | ELISA: 1 µg/ml, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 20 µl |
| Size 2 | 100 µl |
| Size 3 | 2 × 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P15374 |
| Gene ID | 7347 |
| NCBI Accession | NP_005993.1 |
| Alias | UCH-L3,Ubiquitin thioesterase L3 |
| Background | Antibody anti-UCHL3 |
| Status | RUO |
| Note | Concentration: > 0.2 mg/ml - |
Descripción
UCHL3 is a deubiquitinating enzyme involved in ubiquitin recycling and protein turnover, ensuring cellular protein quality control and homeostasis. It cleaves ubiquitin precursors and removes ubiquitin chains from target proteins, preventing their premature degradation by the proteasome. UCHL3 is ubiquitously expressed and plays roles in DNA repair, apoptosis, and embryonic development. It is particularly essential for spermatogenesis, where it regulates chromatin remodeling and germ cell differentiation. Loss of UCHL3 function is associated with impaired cellular proteostasis, genomic instability, and reproductive defects. Studies show its involvement in tumor progression, where dysregulation of UCHL3 alters protein degradation pathways, contributing to cancer cell survival. Knockout models exhibit defects in germ cell development, growth retardation, and increased sensitivity to cellular stress, underscoring its importance in ubiquitin regulation, cellular stability, and reproductive biology.
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