Ubiquitin Carboxyl-Terminal Hydrolase 37 (USP37) Antibody

Name: Ubiquitin Carboxyl-Terminal Hydrolase 37 (USP37) Antibody
Brand: Abbexa
SKU: abx036930
Price: 357.5 EUR
Availability: OnlineOnly

357.5€ (100 µg)

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Ubiquitin Carboxyl-Terminal Hydrolase 37 (USP37) Antibody

Description

Rabbit Polyclonal against the USP37 protein.

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Product specifications

Category	Primary Antibodies
Immunogen Target	Ubiquitin Carboxyl-Terminal Hydrolase 37 (USP37)
Host	Rabbit
Reactivity	Human
Recommended Dilution	ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Clonality	Polyclonal
Conjugation	Unconjugated
Isotype	IgG
Purification	Purified by Protein A/G column chromatography.
Size 1	100 µg
Size 2	1 mg
Form	Lyophilized
Tested Applications	ELISA, WB
Buffer	Prior to lyophilization: 0.02% NaN3.
Availability	Shipped within 7-15 working days.
Storage	Store at -20 °C. Avoid repeated freeze/thaw cycles.
Dry Ice	No
UniProt ID	BC050461
Background	Antibody anti-USP37
Status	RUO
Note	Concentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. -

Descripción

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USP37 antibody

Deubiquitinase that antagonizes the anaphase-promoting complex(APC/C) during G1/S transition by mediating deubiquitination of cyclin-A(CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A(CCNA1 and CCNA2).

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