Tyrosine Kinase 2 (Tyk2) Antibody
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Description
TYK2 (tyrosine kinase 2),with 1187-amino acid protein (about 131kDa), belongs to the family of non-receptor janus tyrosine kinases, which also includes Jak1, Jak2, and Jak3. Kinases of the Jak family regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. TYK2 is activated by a variety of cytokines: IFN alpha, IFN beta, IL-6, IL-10, IL-12, and IL-13 and promotes IFN gamma production by Th1-type CD4 cells. TYK2 can be viewed as a dual-function Jak, mediating both pro-inflammatory and anti-inflammatory cytokine responses. TYK2 is also an important regulator of lymphoid tumor surveillance.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Tyrosine Kinase 2 (TYK2) Immunogen: Purified recombinant fragment of Tyk2 expressed in E. coli. |
| Host | Mouse |
| Reactivity | Human |
| Assay Type | Concentration: Not determined. |
| Recommended Dilution | ELISA: 1/10000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Observed MW | 140 kDa |
| Purification | Unpurified ascites. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | Ascitic fluid containing 0.03% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P29597 |
| Gene ID | 7297 |
| OMIM | 176941 |
| Background | Antibody anti-Tyk2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
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TYK2 (tyrosine kinase 2),with 1187-amino acid protein (about 131kDa), belongs to the family of non-receptor janus tyrosine kinases, which also includes Jak1, Jak2, and Jak3. Kinases of the Jak family regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. TYK2 is activated by a variety of cytokines: IFN alpha, IFN beta, IL-6, IL-10, IL-12, and IL-13 and promotes IFN gamma production by Th1-type CD4 cells. TYK2 can be viewed as a dual-function Jak, mediating both pro-inflammatory and anti-inflammatory cytokine responses. TYK2 is also an important regulator of lymphoid tumor surveillance.
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