TYROBP encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL.
Primary Antibodies
Polyclonal
Human
TYRO Protein Tyrosine Kinase Binding Protein (TYROBP)
Rabbit
Unconjugated
Liquid
ELISA, WB, IHC, FCM
Purified through a protein A column, followed by peptide affinity purification.
PBS containing 0.09% sodium azide.
80 µl
400 µl
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
TYROBP
No
Shipped within 5-10 working days.
This product is for research use only.
Precio a consultar
Ver másTYROBP Antibody is a Rabbit Polyclonal antibody against TYROBP. This gene encodes a transmembrane signaling polypeptide ...
175€ (20 µl)
Ver másTYROBP encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (I...
281.25€ (80 µl)
Ver más