Tumor Necrosis Factor Receptor Superfamily Member 13B / CD267 (TNFRSF13B) Antibody
637€ (100 µl)
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935106861
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name
Tumor Necrosis Factor Receptor Superfamily Member 13B / CD267 (TNFRSF13B) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx116362
tested applications
ELISA, WB
Description
Tumor Necrosis Factor Receptor Superfamily, Member 13B Antibody is a Rabbit Polyclonal antibody against Tumor Necrosis Factor Receptor Superfamily, Member 13B.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Tumor Necrosis Factor Receptor Superfamily Member 13B / CD267 (TNFRSF13B) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, containing 0.02% Sodium Azide and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O14836 |
| Gene ID | 23495 |
| NCBI Accession | NP_036584.1, NM_012452.2 |
| OMIM | 240500 |
| Alias | Tumor necrosis factor receptor superfamily member 13B,CVID,RYZN,TACI,CD267,CVID2,IGAD2,TNFRSF14B,Transmembrane activator and CAML interactor |
| Background | Antibody anti-TNFRSF13B |
| Status | RUO |
Descripción
TNFRSF13B, also known as TACI (Transmembrane Activator and CAML Interactor), is a critical receptor in the immune system, specifically involved in B cell biology. TNFRSF13B belongs to the tumor necrosis factor receptor superfamily (TNFRSF) and plays an essential role in immune regulation by binding ligands such as APRIL (a proliferation-inducing ligand) and BAFF (B-cell activating factor). These interactions are vital for B cell survival, proliferation, and differentiation, particularly in the context of generating long-lasting immune responses and maintaining immune homeostasis. Mutations in TNFRSF13B have been linked to various immunodeficiency disorders, such as Common Variable Immunodeficiency (CVID) and IgA deficiency. These conditions are associated with impaired antibody production, resulting in increased susceptibility to infections and autoimmune complications. Due to its importance in regulating immune responses, TNFRSF13B is studied intensively as a therapeutic target for both immunodeficiency disorders and autoimmune diseases where B cell activity is dysregulated.
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