Tumor Necrosis Factor Ligand Superfamily Member 4 / OX40L (TNFSF4) Antibody
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Description
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF4/OX4. It is found to be involved in T cell antigen-presenting cell (APC) interactions. In surface Ig and CD40-stimulated B cells, this cytokine along with CD70 has been shown to provide CD28-independent costimulatory signals to T cells. This protein and its receptor are reported to directly mediate adhesion of activated T cells to vascular endothelial cells.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Tumor Necrosis Factor Ligand Superfamily Member 4 / OX40L (TNFSF4) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P23510 |
| Alias | Tumor necrosis factor ligand superfamily member 4,GP34,CD252,OX4OL,TXGP1,CD134L,OX-40L,TNLG2B,OX40 ligand,OX40L,TAX transcriptionally-activated glycoprotein 1 |
| Background | Antibody anti-TNFSF4 |
| Status | RUO |
Descripción
TNFSF4, also known as OX40 ligand (OX40L) or CD252, is a member of the tumor necrosis factor (TNF) superfamily. It plays a crucial role in the immune system by interacting with the OX40 receptor (CD134), primarily expressed on activated T cells. This interaction contributes to T-cell activation, proliferation, and survival, and it is particularly important for the adaptive immune response. OX40L is predominantly expressed on activated antigen-presenting cells, such as dendritic cells, B cells, and macrophages, and its role in enhancing T-cell function is integral to immune response against infections, cancer, and during inflammatory processes. OX40L has gained significant attention for its role in immune checkpoint pathways, which are mechanisms that regulate immune response strength and duration. Because of its function in enhancing T-cell activity, it has been studied as a target for immunotherapies in cancer, autoimmune disorders, and infectious diseases. Additionally, dysregulation of the TNFSF4 gene, which encodes OX40L, has been implicated in several inflammatory and autoimmune diseases, including systemic lupus erythematosus (SLE) and rheumatoid arthritis.
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Tumor Necrosis Factor Ligand Superfamily Member 4 / OX40L (TNFSF4) Antibody
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF4/OX4. It is found to be involved in T cell antigen-presenting cell (APC) interactions. In surface Ig and CD40-stimulated B cells, this cytokine along with CD70 has been shown to provide CD28-independent costimulatory signals to T cells. This protein and its receptor are reported to directly mediate adhesion of activated T cells to vascular endothelial cells. This antibody is supplied as crude ascites.
Ver Producto
Tumor Necrosis Factor Ligand Superfamily Member 4 / OX40L (TNFSF4) Antibody
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF4/OX4. It is found to be involved in T cell antigen-presenting cell (APC) interactions. In surface Ig and CD40-stimulated B cells, this cytokine along with CD70 has been shown to provide CD28-independent costimulatory signals to T cells. This protein and its receptor are reported to directly mediate adhesion of activated T cells to vascular endothelial cells.
Ver Producto