Transmembrane P24 Trafficking Protein 3 (TMED3) Antibody
357.5€ (100 µg)
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name
Transmembrane P24 Trafficking Protein 3 (TMED3) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx145015
tested applications
ELISA, WB, IHC
Description
TMED3 Antibody is a Rabbit Polyclonal against TMED3.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Transmembrane P24 Trafficking Protein 3 (TMED3) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by antigen affinity column chromatography. |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Lyophilized |
| Tested Applications | ELISA, WB, IHC |
| Buffer | Prior to lyophilization: 1% BSA and 0.02% NaN3. |
| Availability | Shipped within 7-15 working days. |
| Storage | Store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| NCBI Accession | BC000027 |
| Alias | C15orf22, P24B, p24g4, p24gamma4, p26,p24 family protein gamma-4,p24gamma4 p26 |
| Background | Antibody anti-TMED3 |
| Status | RUO |
| Note | Concentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. - |
Descripción
TMED3 is a member of the p24 protein family, functioning as a cargo receptor in the early secretory pathway that mediates protein transport between the endoplasmic reticulum (ER), the ER-Golgi intermediate compartment (ERGIC), and the Golgi apparatus. It regulates the selection and packaging of specific cargo proteins into COPII-coated vesicles for export from the ER and coordinates vesicle retrieval via COPI machinery. TMED3 plays an important role in maintaining Golgi structure and the balance of protein flux through the secretory system. Beyond its trafficking role, TMED3 is implicated in Wnt/β-catenin signaling, where it modulates receptor localization and pathway activation critical for cell proliferation, differentiation, and development. Dysregulation of TMED3 contributes to cancers, including colorectal and hepatocellular carcinoma, where altered protein trafficking enhances oncogenic signaling. Knockdown studies reveal impaired vesicular transport, Golgi disorganization, and disrupted Wnt signaling, highlighting its essential role in secretory trafficking, Golgi homeostasis, and signaling regulation.
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