Transmembrane P24 Trafficking Protein 3 (TMED3) Antibody
292.5€ (80 µl)
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Name
Transmembrane P24 Trafficking Protein 3 (TMED3) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx029578
Tested Applications
ELISA, WB
Description
The function of this protein remains unknown.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Transmembrane P24 Trafficking Protein 3 (TMED3) Immunogen: KLH-conjugated synthetic peptide between 149-178 amino acids from the C-terminal region of human TMED3. |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 24.8 kDa |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9Y3Q3 |
| Alias | C15orf22, P24B, p24g4, p24gamma4, p26,p24 family protein gamma-4,p24gamma4 p26 |
| Background | Antibody anti-TMED3 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
TMED3 is a member of the p24 protein family, functioning as a cargo receptor in the early secretory pathway that mediates protein transport between the endoplasmic reticulum (ER), the ER-Golgi intermediate compartment (ERGIC), and the Golgi apparatus. It regulates the selection and packaging of specific cargo proteins into COPII-coated vesicles for export from the ER and coordinates vesicle retrieval via COPI machinery. TMED3 plays an important role in maintaining Golgi structure and the balance of protein flux through the secretory system. Beyond its trafficking role, TMED3 is implicated in Wnt/β-catenin signaling, where it modulates receptor localization and pathway activation critical for cell proliferation, differentiation, and development. Dysregulation of TMED3 contributes to cancers, including colorectal and hepatocellular carcinoma, where altered protein trafficking enhances oncogenic signaling. Knockdown studies reveal impaired vesicular transport, Golgi disorganization, and disrupted Wnt signaling, highlighting its essential role in secretory trafficking, Golgi homeostasis, and signaling regulation.
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