Transmembrane Emp24 Domain-Containing Protein 6 (TMED6) Antibody (FITC)
169€ (20 µg)
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Name
Transmembrane Emp24 Domain-Containing Protein 6 (TMED6) Antibody (FITC)
Category
Primary Antibodies
Provider
Abbexa
Reference
abx348268
Description
Transmembrane Emp24 Domain-Containing Protein 6 (TMED6) Antibody (FITC) is a Rabbit Polyclonal antibody conjugated to FITC for the detection of Human TMED6.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Transmembrane Emp24 Domain-Containing Protein 6 (TMED6) Immunogen: Recombinant Human Transmembrane emp24 domain-containing protein 6 protein (22-170 AA) |
| Host | Rabbit |
| Reactivity | Human |
| Detection Method | Laser Line: 488 Excitation/Emission: 499/515 |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | FITC |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G chromatography. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q8WW62 |
| Alias | PRO34237, SPLL9146, p24g5,p24 family protein gamma-5,p24gamma5 |
| Background | Antibody anti-TMED6 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
TMED6 is a member of the p24 protein family, which regulates protein trafficking between the endoplasmic reticulum (ER), the ER-Golgi intermediate compartment (ERGIC), and the Golgi apparatus. TMED6 functions as a cargo receptor, facilitating the selection and packaging of secretory and membrane proteins into COPII-coated vesicles for ER export. It also participates in the retrieval of misfolded or redundant proteins back to the ER through COPI-mediated transport. TMED6 plays a role in maintaining proper protein quality control, ensuring efficient maturation and trafficking of proteins critical for cellular homeostasis. It is highly expressed in secretory tissues and immune cells, where it supports organelle organization, immune response modulation, and cellular communication. Dysregulation of TMED6 has been linked to metabolic disorders and cancers, where altered vesicle dynamics impair protein secretion and cellular growth. Knockdown studies reveal defects in protein trafficking, ER stress accumulation, and impaired Golgi organization, highlighting its role in secretory pathway regulation, protein homeostasis, and cellular integrity.
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