Transmembrane Emp24 Domain-Containing Protein 6 (TMED6) Antibody
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Description
TMED6 (transmembrane emp24 domain-containing protein 6) is a 240 amino acid single-pass type I membrane protein that belongs to the EMP24/GP25L family and contains one GOLD domain. The gene that encodes TMED6 contains around 8, 564 bases and maps to human chromosome 16q22.1. Encoding over 900 genes and consisting of approximately 90 million base pairs, chromosome 16 makes up nearly 3% of the human genome and is associated with a variety of genetic disorders. The GAN gene is located on chromosome 16 and, when mutated, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. Alterations in the CREB gene and NOD2 gene, both of which are located on chromosome 16, result in Rubinstein-Taybi syndrome and Crohn's disease, respectively. An association with systemic lupus erythematosis and a number of other autoimmune disorders with the pericentromeric region of chromosome 16 has led to the identification of SLC5A11 as a potential autoimmune modifier.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Transmembrane Emp24 Domain-Containing Protein 6 (TMED6) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q8WW62 |
| Alias | PRO34237, SPLL9146, p24g5,p24 family protein gamma-5,p24gamma5 |
| Background | Antibody anti-TMED6 |
| Status | RUO |
Descripción
TMED6 is a member of the p24 protein family, which regulates protein trafficking between the endoplasmic reticulum (ER), the ER-Golgi intermediate compartment (ERGIC), and the Golgi apparatus. TMED6 functions as a cargo receptor, facilitating the selection and packaging of secretory and membrane proteins into COPII-coated vesicles for ER export. It also participates in the retrieval of misfolded or redundant proteins back to the ER through COPI-mediated transport. TMED6 plays a role in maintaining proper protein quality control, ensuring efficient maturation and trafficking of proteins critical for cellular homeostasis. It is highly expressed in secretory tissues and immune cells, where it supports organelle organization, immune response modulation, and cellular communication. Dysregulation of TMED6 has been linked to metabolic disorders and cancers, where altered vesicle dynamics impair protein secretion and cellular growth. Knockdown studies reveal defects in protein trafficking, ER stress accumulation, and impaired Golgi organization, highlighting its role in secretory pathway regulation, protein homeostasis, and cellular integrity.
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Transmembrane Emp24 Domain-Containing Protein 6 (TMED6) Antibody
TMED6 (transmembrane emp24 domain-containing protein 6) is a 240 amino acid single-pass type I membrane protein that belongs to the EMP24/GP25L family and contains one GOLD domain. The gene that encodes TMED6 contains around 8, 564 bases and maps to human chromosome 16q22.1. Encoding over 900 genes and consisting of approximately 90 million base pairs, chromosome 16 makes up nearly 3% of the human genome and is associated with a variety of genetic disorders. The GAN gene is located on chromosome 16 and, when mutated, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. Alterations in the CREB gene and NOD2 gene, both of which are located on chromosome 16, result in Rubinstein-Taybi syndrome and Crohn's disease, respectively. An association with systemic lupus erythematosis and a number of other autoimmune disorders with the pericentromeric region of chromosome 16 has led to the identification of SLC5A11 as a potential autoimmune modifier.
Ver Producto
Transmembrane Emp24 Domain-Containing Protein 6 (TMED6) Antibody
TMED6 Antibody is a Rabbit Polyclonal against TMED6.
Ver ProductoTransmembrane Emp24 Domain-Containing Protein 6 (TMED6) Antibody
TMED6 Antibody is a Rabbit Polyclonal against TMED6.
Ver Producto