Transmembrane Emp24 Domain-Containing Protein 6 (TMED6) Antibody
357.5€ (100 µg)
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Name
Transmembrane Emp24 Domain-Containing Protein 6 (TMED6) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx145004
Tested Applications
ELISA, IHC
Description
TMED6 Antibody is a Rabbit Polyclonal against TMED6.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Transmembrane Emp24 Domain-Containing Protein 6 (TMED6) Immunogen: Recombinant fragment corresponding to 25-190 AA of human TMED6. |
| Host | Rabbit |
| Reactivity | Human |
| Assay Type | Concentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. |
| Recommended Dilution | ELISA: 1/20000 - 1/80000, IHC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by antigen affinity column chromatography. |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Lyophilized |
| Tested Applications | ELISA, IHC |
| Buffer | Prior to lyophilization: 1% BSA and 0.02% NaN3. |
| Availability | Shipped within 7-15 working days. |
| Storage | Store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| NCBI Accession | BC020827 |
| Alias | PRO34237, SPLL9146, p24g5,p24 family protein gamma-5,p24gamma5 |
| Background | Antibody anti-TMED6 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
TMED6 is a member of the p24 protein family, which regulates protein trafficking between the endoplasmic reticulum (ER), the ER-Golgi intermediate compartment (ERGIC), and the Golgi apparatus. TMED6 functions as a cargo receptor, facilitating the selection and packaging of secretory and membrane proteins into COPII-coated vesicles for ER export. It also participates in the retrieval of misfolded or redundant proteins back to the ER through COPI-mediated transport. TMED6 plays a role in maintaining proper protein quality control, ensuring efficient maturation and trafficking of proteins critical for cellular homeostasis. It is highly expressed in secretory tissues and immune cells, where it supports organelle organization, immune response modulation, and cellular communication. Dysregulation of TMED6 has been linked to metabolic disorders and cancers, where altered vesicle dynamics impair protein secretion and cellular growth. Knockdown studies reveal defects in protein trafficking, ER stress accumulation, and impaired Golgi organization, highlighting its role in secretory pathway regulation, protein homeostasis, and cellular integrity.
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