Transmembrane Emp24 Domain-Containing Protein 10 (TMED10) Antibody
169€ (20 µl)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Transmembrane Emp24 Domain-Containing Protein 10 (TMED10) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx322405
tested applications
ELISA, WB, IHC
Description
TMED10 Antibody is a Rabbit Polyclonal against TMED10.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Transmembrane Emp24 Domain-Containing Protein 10 (TMED10) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1/1000 - 1/5000, IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 20 µl |
| Size 2 | 50 µl |
| Size 3 | 100 µl |
| Size 4 | 200 µl |
| Size 5 | 1 ml |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P49755 |
| Gene ID | 10972 |
| OMIM | 605406 |
| Alias | TMP21,p23,TMP21,p24d1,S31I125,Tmp-21-I,S31III125,P24(DELTA) |
| Background | Antibody anti-TMED10 |
| Status | RUO |
Descripción
TMED10, also known as p24δ1, is a critical component of the p24 family involved in regulating vesicular trafficking between the endoplasmic reticulum (ER), ER-Golgi intermediate compartment (ERGIC), and Golgi apparatus. It functions as a cargo receptor, facilitating the efficient transport of membrane and secretory proteins by interacting with COPII and COPI coat complexes during vesicle budding and retrieval. TMED10 plays an essential role in maintaining Golgi organization, protein sorting, and ER homeostasis, ensuring the proper maturation and localization of secretory proteins. It is ubiquitously expressed and is particularly abundant in rapidly dividing and secretory tissues. TMED10 has also been implicated in cellular signaling, including Wnt signaling and autophagy, where it modulates receptor trafficking and degradation pathways. Dysregulation of TMED10 is associated with neurodegenerative diseases, immune dysfunction, and cancers, where defective trafficking leads to protein mislocalization and stress. Knockdown studies reveal disrupted Golgi morphology, impaired protein secretion, and increased ER stress, highlighting its essential role in vesicular transport, protein homeostasis, and signaling regulation.
Related Products
TMED10 antibody
Ver Producto
Recombinant Human TMED10
Ver Producto
Transmembrane Emp24 Domain-Containing Protein 10 (TMED10) Antibody
TMED10 Antibody is a Rabbit Polyclonal antibody against TMED10. This gene is a member of the EMP24/GP25L/p24 family and encodes a protein with a GOLD domain. This type I membrane protein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking. The protein is also a member of a heteromeric secretase complex and regulates the complex's gamma-secretase activity without affecting its epsilon-secretase activity. Mutations in this gene have been associated with early-onset familial Alzheimer's disease. This gene has a pseudogene on chromosome 8.
Ver Producto