Transmembrane Emp24 Domain-Containing Protein 10 (TMED10) Antibody
357.5€ (100 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Transmembrane Emp24 Domain-Containing Protein 10 (TMED10) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx145297
Tested Applications
ELISA, WB, IHC
Description
TMED10 Antibody is a Rabbit Polyclonal against TMED10.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Transmembrane Emp24 Domain-Containing Protein 10 (TMED10) Immunogen: Recombinant fragment corresponding to 34-180 AA of human TMED10. |
| Host | Rabbit |
| Reactivity | Human |
| Assay Type | Concentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. |
| Recommended Dilution | ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Observed MW: 25 kDa |
| Purification | Purified by antigen affinity column chromatography. |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Lyophilized |
| Tested Applications | ELISA, WB, IHC |
| Buffer | Prior to lyophilization: 1% BSA and 0.02% NaN3. |
| Availability | Shipped within 7-15 working days. |
| Storage | Store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| NCBI Accession | BC001496 |
| Alias | TMP21,p23,TMP21,p24d1,S31I125,Tmp-21-I,S31III125,P24(DELTA) |
| Background | Antibody anti-TMED10 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
TMED10, also known as p24δ1, is a critical component of the p24 family involved in regulating vesicular trafficking between the endoplasmic reticulum (ER), ER-Golgi intermediate compartment (ERGIC), and Golgi apparatus. It functions as a cargo receptor, facilitating the efficient transport of membrane and secretory proteins by interacting with COPII and COPI coat complexes during vesicle budding and retrieval. TMED10 plays an essential role in maintaining Golgi organization, protein sorting, and ER homeostasis, ensuring the proper maturation and localization of secretory proteins. It is ubiquitously expressed and is particularly abundant in rapidly dividing and secretory tissues. TMED10 has also been implicated in cellular signaling, including Wnt signaling and autophagy, where it modulates receptor trafficking and degradation pathways. Dysregulation of TMED10 is associated with neurodegenerative diseases, immune dysfunction, and cancers, where defective trafficking leads to protein mislocalization and stress. Knockdown studies reveal disrupted Golgi morphology, impaired protein secretion, and increased ER stress, highlighting its essential role in vesicular transport, protein homeostasis, and signaling regulation.
Productos relacionados
Transmembrane Emp24 Domain-Containing Protein 10 (TMED10) Antibody
This gene is a member of the EMP24/GP25L/p24 family and encodes a protein with a GOLD domain. This type I membrane prote…
Ver producto Transmembrane Emp24 Domain-Containing Protein 10 (TMED10) Antibody
Transmembrane Emp24-Like Trafficking Protein 10 (Yeast) Antibody is a Rabbit Polyclonal antibody against Transmembrane E…
Ver producto Transmembrane Emp24 Domain-Containing Protein 10 (TMED10) Antibody
TMED10 Antibody is a Rabbit Polyclonal against TMED10.…
Ver producto