Transmembrane Emp24 Domain-Containing Protein 10 (TMED10) Antibody

Este producto es parte de TMED - Transmembrane emp24 domain-containing
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357.5€ (100 µg)

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935106861
info@markelab.com
name
Transmembrane Emp24 Domain-Containing Protein 10 (TMED10) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx145297
tested applications
ELISA, WB, IHC

Description

TMED10 Antibody is a Rabbit Polyclonal against TMED10.

Documents del producto

Instrucciones
Data sheet
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Product specifications

Category
Primary Antibodies
Immunogen Target
Transmembrane Emp24 Domain-Containing Protein 10 (TMED10)
Host
Rabbit
Reactivity
Human
Recommended Dilution
ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purification
Purified by antigen affinity column chromatography.
Size 1
100 µg
Size 2
1 mg
Form
Lyophilized
Tested Applications
ELISA, WB, IHC
Buffer
Prior to lyophilization: 1% BSA and 0.02% NaN3.
Availability
Shipped within 7-15 working days.
Storage
Store at -20 °C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
NCBI Accession
BC001496
Alias
TMP21,p23,TMP21,p24d1,S31I125,Tmp-21-I,S31III125,P24(DELTA)
Background
Antibody anti-TMED10
Status
RUO
Note
Concentration: Lyophilized form: Not applicable.  After reconstitution: 1 mg/ml. -

Descripción

TMED10, also known as p24δ1, is a critical component of the p24 family involved in regulating vesicular trafficking between the endoplasmic reticulum (ER), ER-Golgi intermediate compartment (ERGIC), and Golgi apparatus. It functions as a cargo receptor, facilitating the efficient transport of membrane and secretory proteins by interacting with COPII and COPI coat complexes during vesicle budding and retrieval. TMED10 plays an essential role in maintaining Golgi organization, protein sorting, and ER homeostasis, ensuring the proper maturation and localization of secretory proteins. It is ubiquitously expressed and is particularly abundant in rapidly dividing and secretory tissues. TMED10 has also been implicated in cellular signaling, including Wnt signaling and autophagy, where it modulates receptor trafficking and degradation pathways. Dysregulation of TMED10 is associated with neurodegenerative diseases, immune dysfunction, and cancers, where defective trafficking leads to protein mislocalization and stress. Knockdown studies reveal disrupted Golgi morphology, impaired protein secretion, and increased ER stress, highlighting its essential role in vesicular transport, protein homeostasis, and signaling regulation.

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TMED10 Antibody is a Rabbit Polyclonal antibody against TMED10. This gene is a member of the EMP24/GP25L/p24 family and encodes a protein with a GOLD domain. This type I membrane protein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking. The protein is also a member of a heteromeric secretase complex and regulates the complex's gamma-secretase activity without affecting its epsilon-secretase activity. Mutations in this gene have been associated with early-onset familial Alzheimer's disease. This gene has a pseudogene on chromosome 8.

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