Transmembrane Emp24 Domain-Containing Protein 10 (TMED10) Antibody
637€ (100 µl)
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Name
Transmembrane Emp24 Domain-Containing Protein 10 (TMED10) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx116230
Tested Applications
ELISA, WB, IHC, IF/ICC
Description
Transmembrane Emp24-Like Trafficking Protein 10 (Yeast) Antibody is a Rabbit Polyclonal antibody against Transmembrane Emp24-Like Trafficking Protein 10 (Yeast).
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Transmembrane Emp24 Domain-Containing Protein 10 (TMED10) Immunogen: Human TMED10. |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Buffer | PBS, pH 7.3, containing 0.1% Sodium Azide and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P49755 |
| Gene ID | 10972 |
| OMIM | 605406 |
| Alias | TMP21,p23,TMP21,p24d1,S31I125,Tmp-21-I,S31III125,P24(DELTA) |
| Background | Antibody anti-TMED10 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
TMED10, also known as p24δ1, is a critical component of the p24 family involved in regulating vesicular trafficking between the endoplasmic reticulum (ER), ER-Golgi intermediate compartment (ERGIC), and Golgi apparatus. It functions as a cargo receptor, facilitating the efficient transport of membrane and secretory proteins by interacting with COPII and COPI coat complexes during vesicle budding and retrieval. TMED10 plays an essential role in maintaining Golgi organization, protein sorting, and ER homeostasis, ensuring the proper maturation and localization of secretory proteins. It is ubiquitously expressed and is particularly abundant in rapidly dividing and secretory tissues. TMED10 has also been implicated in cellular signaling, including Wnt signaling and autophagy, where it modulates receptor trafficking and degradation pathways. Dysregulation of TMED10 is associated with neurodegenerative diseases, immune dysfunction, and cancers, where defective trafficking leads to protein mislocalization and stress. Knockdown studies reveal disrupted Golgi morphology, impaired protein secretion, and increased ER stress, highlighting its essential role in vesicular transport, protein homeostasis, and signaling regulation.
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