Transcription Factor AP-2-Beta (TFAP2B) Antibody

Background

TFAP2B, a member of the AP-2 transcription factor family, regulates gene expression by binding to GC-rich DNA sequences in promoter regions. It plays a key role in embryonic development, particularly in neural crest formation, cardiovascular system development, and kidney morphogenesis. TFAP2B contributes to cell proliferation, differentiation, and survival by controlling the transcription of genes involved in apoptosis, cell adhesion, and growth. Mutations in TFAP2B are associated with autosomal dominant Char syndrome, a congenital disorder characterized by heart defects, limb anomalies, and facial dysmorphisms. TFAP2B also plays a role in tumorigenesis, where its altered expression influences cell cycle progression, epithelial-mesenchymal transition (EMT), and metastasis in cancers such as breast and neuroblastoma. Knockout studies show developmental defects in cardiovascular structures and impaired neural crest cell migration, highlighting TFAP2B's essential role in organ development, tissue differentiation, and cell fate determination.