Transcription Factor AP-2-Beta (TFAP2B) Antibody
637€ (100 µl)
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935106861
info@markelab.com
name
Transcription Factor AP-2-Beta (TFAP2B) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx116159
tested applications
ELISA, WB
Description
Transcription Factor Ap-2 Beta (Activating Enhancer Binding Protein 2 Beta) Antibody is a Rabbit Polyclonal antibody against Transcription Factor Ap-2 Beta (Activating Enhancer Binding Protein 2 Beta).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Transcription Factor AP-2-Beta (TFAP2B) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, containing 0.1% Sodium Azide and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q92481 |
| Gene ID | 7021 |
| NCBI Accession | NP_003212.2, NM_003221.3 |
| OMIM | 169100 |
| Alias | AP-2B,AP-2beta,AP2-B,PDA2,Activating enhancer-binding protein 2-beta |
| Background | Antibody anti-TFAP2B |
| Status | RUO |
Descripción
TFAP2B, a member of the AP-2 transcription factor family, regulates gene expression by binding to GC-rich DNA sequences in promoter regions. It plays a key role in embryonic development, particularly in neural crest formation, cardiovascular system development, and kidney morphogenesis. TFAP2B contributes to cell proliferation, differentiation, and survival by controlling the transcription of genes involved in apoptosis, cell adhesion, and growth. Mutations in TFAP2B are associated with autosomal dominant Char syndrome, a congenital disorder characterized by heart defects, limb anomalies, and facial dysmorphisms. TFAP2B also plays a role in tumorigenesis, where its altered expression influences cell cycle progression, epithelial-mesenchymal transition (EMT), and metastasis in cancers such as breast and neuroblastoma. Knockout studies show developmental defects in cardiovascular structures and impaired neural crest cell migration, highlighting TFAP2B's essential role in organ development, tissue differentiation, and cell fate determination.
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TFAP2B antibody
Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-beta appears to be required for normal face and limb development and for proper terminal differentiation and function of renal tubular epithelia.
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