Toll Like Receptor 9 (TLR9) Antibody
741€ (1 ml)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Toll Like Receptor 9 (TLR9) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx174846
Tested Applications
WB, IHC, IF/ICC
Description
This product is currently in development. The lead time for this product may be several months. Please contact us at
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Toll Like Receptor 9 (TLR9) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Purification | Purified by Protein A and Protein G affinity chromatography. |
| Size 1 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Please enquire. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | Toll-like receptor 9,CD289 |
| Background | Antibody anti-TLR9 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Toll-like receptor 9 (TLR9) is an integral component of the immune system and a member of the Toll-like receptor (TLR) family, primarily involved in the recognition of pathogen-associated molecular patterns (PAMPs) within microbial DNA. TLR9 is uniquely specialized to detect unmethylated CpG motifs in DNA, which are frequently found in bacterial and viral genomes but rare in vertebrate DNA due to methylation. This distinction allows TLR9 to effectively recognize pathogenic DNA and initiate immune responses against infections. By detecting microbial DNA, TLR9 plays a pivotal role in the innate immune response and contributes to the activation of adaptive immunity. TLR9 is expressed in plasmacytoid dendritic cells (pDCs), B cells, and monocytes/macrophages, with its expression localized to the endosomes of these cells. This intracellular positioning is essential for its function, as it enables the receptor to sample nucleic acids from pathogens engulfed in endosomal compartments. Upon recognizing CpG motifs, TLR9 initiates a signaling cascade that promotes cytokine production and type I interferon release, critical for mounting an immune defense against pathogens and influencing the maturation of dendritic cells and the activation of T and B cells.
Productos relacionados
Toll-Like Receptor 9 (TLR9) Antibody
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pa…
Ver producto
Human Toll-Like Receptor 9 (TLR9) ELISA Kit
Human Toll-Like Receptor 9 (TLR9) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Toll-Like…
Ver producto
Rat Toll-Like Receptor 9 (TLR9) ELISA Kit
Rat Toll-Like Receptor 9 (TLR9) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat Toll-Like Rec…
Ver producto