Toll-Like Receptor 9 (TLR9) Antibody
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Pida mas información
935106861
info@markelab.com
Precio
292.5€ (80 µl)
Antibody anti-TLR9
proveedor
Abbexareference
abx027559Tested Applications
ELISA, WB, FCMreactivity
Humanstatus
RUOclonality
PolyclonalDescripción
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is preferentially expressed in immune cell rich tissues, such as spleen, lymph node, bone marrow and peripheral blood leukocytes. Studies in mice and human indicate that this receptor mediates cellular response to unmethylated CpG dinucleotides in bacterial DNA to mount an innate immune response.
Background
Toll-like receptor 9 (TLR9) is an integral component of the immune system and a member of the Toll-like receptor (TLR) family, primarily involved in the recognition of pathogen-associated molecular patterns (PAMPs) within microbial DNA. TLR9 is uniquely specialized to detect unmethylated CpG motifs in DNA, which are frequently found in bacterial and viral genomes but rare in vertebrate DNA due to methylation. This distinction allows TLR9 to effectively recognize pathogenic DNA and initiate immune responses against infections. By detecting microbial DNA, TLR9 plays a pivotal role in the innate immune response and contributes to the activation of adaptive immunity. TLR9 is expressed in plasmacytoid dendritic cells (pDCs), B cells, and monocytes/macrophages, with its expression localized to the endosomes of these cells. This intracellular positioning is essential for its function, as it enables the receptor to sample nucleic acids from pathogens engulfed in endosomal compartments. Upon recognizing CpG motifs, TLR9 initiates a signaling cascade that promotes cytokine production and type I interferon release, critical for mounting an immune defense against pathogens and influencing the maturation of dendritic cells and the activation of T and B cells.
Características del producto
category
Primary Antibodies
clonality
Polyclonal
reactivity
Human
immunogen target
Toll-Like Receptor 9 (TLR9)
host
Rabbit
isotype
IgG
conjugation
Unconjugated
form
Liquid
tested applications
ELISA, WB, FCM
purification
Purified through a protein A column, followed by peptide affinity purification.
recommended dilution
WB: 1/1000, FCM: 1/10 - 1/50. Optimal dilutions/concentrations should be determined by the end user.
buffer
PBS containing 0.09% sodium azide.
size 1
80 µl
size 2
400 µl
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
TLR9
dry ice
No
availability
Shipped within 5-10 working days.
alias
Toll-like receptor 9,CD289
uniprot id
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