Toll-Like Receptor 9 (TLR9) Antibody

Este producto es parte de TLR9 - toll like receptor 9
Toll-Like Receptor 9 (TLR9) Antibody

Pida mas información

935106861

info@markelab.com

Precio

292.5€ (80 µl)

Antibody anti-TLR9

proveedor

Abbexa

reference

abx027559

Tested Applications

ELISA, WB, FCM

reactivity

Human

status

RUO

clonality

Polyclonal

Descripción

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is preferentially expressed in immune cell rich tissues, such as spleen, lymph node, bone marrow and peripheral blood leukocytes. Studies in mice and human indicate that this receptor mediates cellular response to unmethylated CpG dinucleotides in bacterial DNA to mount an innate immune response.


Background

Toll-like receptor 9 (TLR9) is an integral component of the immune system and a member of the Toll-like receptor (TLR) family, primarily involved in the recognition of pathogen-associated molecular patterns (PAMPs) within microbial DNA. TLR9 is uniquely specialized to detect unmethylated CpG motifs in DNA, which are frequently found in bacterial and viral genomes but rare in vertebrate DNA due to methylation. This distinction allows TLR9 to effectively recognize pathogenic DNA and initiate immune responses against infections. By detecting microbial DNA, TLR9 plays a pivotal role in the innate immune response and contributes to the activation of adaptive immunity. TLR9 is expressed in plasmacytoid dendritic cells (pDCs), B cells, and monocytes/macrophages, with its expression localized to the endosomes of these cells. This intracellular positioning is essential for its function, as it enables the receptor to sample nucleic acids from pathogens engulfed in endosomal compartments. Upon recognizing CpG motifs, TLR9 initiates a signaling cascade that promotes cytokine production and type I interferon release, critical for mounting an immune defense against pathogens and influencing the maturation of dendritic cells and the activation of T and B cells.

Características del producto

category

Primary Antibodies


clonality

Polyclonal


reactivity

Human


immunogen target

Toll-Like Receptor 9 (TLR9)


host

Rabbit


isotype

IgG


conjugation

Unconjugated


form

Liquid


tested applications

ELISA, WB, FCM


purification

Purified through a protein A column, followed by peptide affinity purification.


recommended dilution

WB: 1/1000, FCM: 1/10 - 1/50. Optimal dilutions/concentrations should be determined by the end user.


buffer

PBS containing 0.09% sodium azide.


size 1

80 µl


size 2

400 µl


storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.


or code

TLR9


dry ice

No


availability

Shipped within 5-10 working days.


alias

Toll-like receptor 9,CD289


Quizá le pueda interesar

Human TLR9(Toll-like receptor 9) ELISA Kit

Human TLR9(Toll-like receptor 9) ELISA Kit

proveedor

FineTest

reference

EH1019

reactivity

human

status

RUO

Precio a consultar

Ver más

Mouse TLR9(Toll-like Receptor 9) ELISA Kit

Mouse TLR9(Toll-like Receptor 9) ELISA Kit

proveedor

FineTest

reference

EM1412

reactivity

mouse

status

RUO

Precio a consultar

Ver más

Rat TLR9(Toll-Like Receptor 9) ELISA Kit

Rat TLR9(Toll-Like Receptor 9) ELISA Kit

proveedor

FineTest

reference

ER1388

reactivity

rat

status

RUO

Precio a consultar

Ver más